A study by David Davila, Niamh M. C. Connolly, Helena Bonner, Petronela Weisová, Heiko Dussmann, Caoimhín G. Concannon, Heinrich J. Huber and Jochen H. M. Prehn was accepted to the high profile journal Cell Death and Differentiation in March 2012. The study involved collaboration between the Centre for Systems Medicine (computational modelling) and the Centre for the Study of Neurological Disorders (biological experimentation). The authors investigated the molecular signalling pathways mediating the apoptotic response of neurons undergoing excitotoxic stress, a process implicated in stroke and neurodegenerative diseases. Systems analysis identified a key network motif (known as a coherent feed-forward loop) that prevents apoptosis during physiological or short-term stress, but translates pathological long-term stress into robust apoptosis activation. This molecular framework thus provides a mechanism for cell fate decision making.
- CSM Researchers and collaborators discover predictive biomarker for key colorectal cancer drug
- MSc students from the Netherlands visit the CSM
- Our miRNAmeConverter package (https://bit.ly/2fFe5BA) now supports miRBase 22!
- PurinesDX conference April 24th RCSI
- ‘Breast-Predict’ have developed a tool that may predict how effective chemotherapy is likely to be in treating triple-negative breast cancer patients.
- GLIOTRAIN : European Training Network PhD Student Position available
- CoEN Award to CSM-Network of Centres of Excellence in Neurodegeneration
- GLIOTRAIN, Brain Tumor Ireland and RCSI Presents Two Public Lectures- Friday March 9th
- Physiology News Letter 2nd Edition January 2018
- JPND fund the CSM and its partners 1.5M