The Centre for Systems Medicine is pleased to announce another speaker to our seminar series,
Prof Dr Christoph Borner
Professor in Medical Cell Research, Institute of Molecular Medicine,
Albert Ludwigs University Freiburg, Germany
Use of viruses and funghi to uncover novel apoptosis signaling pathways
The primary interest of his laboratory is the elucidation of the function of multidomain anti- and pro-apoptotic Bcl-2 family members (Bcl-2, Bcl-xL, Mcl-1, Bax and Bak), the characterization of components of caspase-independent and RNA-virus (SFV)-induced apoptosis signaling, and the mathematical modelling of apoptotic and mitogenic FasL signaling pathways in primary hepatocytes.
Find more details on his homepage.
- A Novel Mitochondrial MAVS/Caspase-8 Platform Links RNA Virus-Induced Innate Antiviral Signaling to Bax/Bak-Independent Apoptosis. El Maadidi S, Faletti L, Berg B, Wenzl C, Wieland K, Chen ZJ, Maurer U, Borner C. J Immunol. 2014 Jan 3.
- Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK. Geissler A, Haun F, Frank DO, Wieland K, Simon MM, Idzko M, Davis RJ, Maurer U, Borner C. Cell Death Differ. 2013 Oct;20(10):1317-29. doi: 10.1038/cdd.2013.78. Epub 2013 Jul 5.
- TNFα-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation. Huai J, Vögtle FN, Jöckel L, Li Y, Kiefer T, Ricci JE, Borner C. J Cell Sci. 2013 Sep 1;126(Pt 17):4015-25. doi: 10.1242/jcs.129999. Epub 2013 Jun 20.
- Non-canonical function of Bax in stress-induced nuclear protein redistribution. Lindenboim L, Ferrando-May E, Borner C, Stein R. Cell Mol Life Sci. 2013 Aug;70(16):3013-27.
The talk is open to everyone and will be held in Houston Lecture Theater, RCSI on 28th of January 2014 at 1:30 pm.