The Centre for Systems Medicine welcomes: Dr. Michael Courtney Turku Centre for Biotechnology, Finland.

Lecture entitled “NOS1AP, an adaptor protein linked to neurological diseases, reveals a novel signalling paradigm”

Venue: Albert L.T. 4pm 11th June 2015

Michael Courtney leads a research group focused on neuronal signaling mechanisms and is currently based at the Turku Centre for Biotechnology, Turku, Finland.

Research: After early investigations of the roles of
JNK signalling in neuronal death and development his group focused on
identifying targetable mechanisms by which NMDA receptor signaling influences
neuronal cell fate via activation of the p38MAPK pathway. One of the major NMDA
receptor pathways regulating p38MAPK involves the ternary complex of NMDA
receptor, PSD95 and nNOS. The lab demonstrated that PSD95/nNOS-dependent
pathways could be inhibited by nNOS-derived peptides, resulting in
neuroprotection. They showed that NMDA receptor activity leads to recruitment
of NOS1AP to nNOS and demonstrated that NOS1AP is required for NMDA-evoked
stress-activated MAPK responses and downstream excitotoxic consequences. They
developed a selective inhibitor peptide of the interaction between NOS1AP and
nNOS, with neuroprotective properties in cell cultures and in vivo (in a
preclinical model of perinatal asphyxia). More recently they identified that
interaction of nNOS with NOS1AP involves an unexpectedly complex interplay
between two distinct interaction sites. Each site is potentially druggable,
thereby providing increased opportunities for therapeutic intervention. This is
of potential interest considering that the NR-PSD95-nNOS complex and
potentially the recruitment of NOS1AP may be involved in some of the most
common causes of death and disability from stroke to neuropathic pain,
depression and anxiety disorders, while NOS1AP has been genetically linked to
schizophrenia, post-traumatic stress disorder, sudden cardiac death and long QT
syndromes. http://www.btk.fi/research/affiliated-groups/courtney-michael-neuronal-signal-pathways

All welcome to attend,

Jochen Prehn

 

Title: Sox2, more than a transcription factor Speaker: Dr. Pengyan Xia

Dr. Pengyan Xia

Sox2, more than a transcription factor

Date: Thursday 30thApril 2015

Dear Colleagues,

The Centre for Systems Medicine is pleased to announce another speaker of our seminar series, Dr Pengyan Xia.

Dr Xia’s research is focussed on
studying development and differentiation of the haematopoietic system, in
particular in self-renewal of haematopoietic stem cells (HSCs) and anti-microbe
activity of white blood cells that derived from HSCs. Specifically, his
research is focussed on signalling platforms that regulate the
self-renewal of HSCs (Xia et al, J Exp Med 2014) as well as extracellular
DNA triggered innate immunity in neutrophils (Xia et al, Nat Immunol 2015).

You are all very welcome to attend, please register at:csm@rcsi.ie

Regards,

Markus Rehm

Centre for Systems Medicine, Department of Physiology and Medical Physics

Royal College of Surgeons in Ireland

Funded by the International Strategic Cooperation
Award (ISCA) Grant Number SFI/13/ISCA/2845 China

MEL-PLEX Worshop Wednesday 6th May 2015

Innovative Approaches in Translational Melanoma Research

MEL-PLEX is a Marie Skłodoswska-Curie
Innovative Training Network funded by Horizon 2020 aiming to train a new
generation of researchers that can navigate confidently between clinical,
academic and private sector environments. As part of its training programme,
MEL-PLEX will hold a training course which will consist of workshop to provide
an overview of the current status of malignant melanoma management and the
field of translational cancer systems biology and systems medicine, followed by
a Transferable Skills course to introduce the new PhD students to basic topics
in scientific research.

The main topics addressed
include:

  • Melanoma
    pathology and treatment
  • Melanoma
    proliferation and migration
  • Kinase
    cascades in melanoma
  • Cell
    death modalities in melanoma
  • Biomarker
    identification and validation
  • Targeted
    drugs and drug development
  • Innovative
    experimental models
  • Applied
    Systems Biology
  • Systems
    Medicine strategies

The workshop entitled “Innovative
Approaches in Translational Melanoma Research” is an open event. Deadline for
registration is April 24th 2015.

For more information and free
registration please contact: melplexETN@rcsi.ie

Venue: Cheyne Lecture Theatre, RCSI, 9am
Wednesday 6th May 2015

Seminar: “Systems pharmacology and pharmacokinetic/pharmacodynamic modelling Oncology”

The Centre for
Systems Medicine is delighted to announce
distinguished  speakers to its 2015 seminar series:
 


Prof. Donald Mager
, Associate Professor of Pharmaceutical Sciences at the University at Buffalo, State University of New York (UB) 
Bio: –http://pharmsci.buffalo.edu/CEPKPD/faculty/MAGER.HTML

and

Prof.Robert Straubinger, Professor of Pharmaceutical
Sciences
at University at Buffalo School of Pharmacy.

Bio: –http://pharmsci.buffalo.edu/CEPKPD/faculty/STRB.HTML

Venue:
Houston Lecture Theatre, RCSI, 4.30 Pm Tuesday 10th March 2015

 

“Abeta oligomers and brain inflammation link synapse failure to neuronal insulin resistance and depression in Alzheimer’s disease”

The Centre for Systems Medicine is delighted to announce another speaker to its 2015 seminar series: 

  Prof. Sergio T. Ferreira.

Professor of Biophysics,Biochemistry, and Neuroscience,

Institute of Biophysics Carlos Chagas Filho & Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio
de Janeiro

 Venue: Albert Lecture Theatre, RCSI, 9am Friday 27th February 2015

Lecture entitled: ‘”Abetaoligomers and brain inflammation link synapse failure to neuronal insulinresistance and depression in Alzheimer’s disease”

Prof. Ferreira has  over  15 years extensive experience in investigating molecular and cellular mechanisms leading to synapse failure and memory loss in Alzheimer’s disease.His main research focus has been on understanding intracellular signaling pathways disrupted or altered when neurons are exposed to Ab oligomers, both in vitro and in vivo.
With particular interest in mechanisms leading to mood alterations in AD and in
shared mechanisms of pathogenesis between AD and diabetes. http://www2.bioqmed.ufrj.br/ldn/sergio.html

All very welcome to attend,

Prof. Jochen Prehn

World Cancer Day Today, 4th February 2015

Cancer Research – Past, Present and Future. Leading Irish and International scientists discuss how cancer research and treatment has evolved in recent years, and what the future holds.

https://www.youtube.com/watch?v=iSi2EO4zyQo&feature=youtu.be

Systems Medicine symposium, BREAST-PREDICT,Irish Cancer
Society Collaborative Cancer Research Centre marking World Cancer Day, 4th February 2015.

 

 

 

 

‘Genetics of Diabetes’ Prof. Graeme Bell, University of Chicago

The Centre for
Systems Medicine is delighted to announce another speaker to its 2015 seminar
series:

Prof. Graeme Bell

University of Chicago

 Venue:
Houston Lecture Theatre, RCSI, 4.30pm Thursday 22nd January 2015

Lecture
entitled:
‘Genetics of Diabetes’

Dr. Bell’s research
focuses on the genetics of diabetes mellitus and the biology of the
insulin-secreting pancreatic beta-cell.

 He and his colleagues
are using various genetic approaches to map and identify the genes that affect
development of type 2 diabetes mellitus as well as diabetic complications. They
carry out studies in both humans and mouse models to determine the mechanisms
by which the diabetes genes they identify affect blood glucose levels. Their
studies of pancreatic beta-cells are focused on understanding the
transcriptional regulatory networks that determine normal cell function.

 http://gbell.bsd.uchicago.edu

http://genes.uchicago.edu/contents/faculty/bell-graeme.htm

  All very welcome to
attend, Prof. Jochen Prehn

 

http://www.systemsmedicineireland.ie/

 

CSM Seminar: Single-cell insights into population-level heterogeneity with examples of MAPK, HIF response and ubiquitination systems

The Centre for Systems Medicine is pleased to announce
another speaker to our seminar series.

Dr. Maciej Dobrzynski

Systems Biology Ireland, University College Dublin, Belfield, Dublin 4

http://www.ucd.ie/research/people/systemsbiologyireland/drmaciejdobrzynski/

Title: Single-cell
insights into population-level heterogeneity with examples of MAPK, HIF
response and ubiquitination systems

Venue: Nightingale Theatre, Thursday 15th
Jan 2015 4pm.

All welcome to attend, 

Prof. Jochen Prehn

 

 

Decisions, decisions: Regulation of apoptotic and necroptotic cell death in skin cancer.

Friday 5th December 2014, at 2.00 pm

Decisions, decisions:  Regulation of apoptotic and necroptotic
cell death
in skin cancer

Dr Martin Leverkus

Section for Molecular Dermatology, Department of Dermatology and
Allergology, Medical Faculty Mannheim, University of Heidelberg, Germany.

Dear Colleagues,

The Centre for Systems Medicine is pleased to announce another speaker of our seminar series.

Dr Leverkus’s research
is focussed on studying regulation of cell death in the skin under
physiological and pathophysiological conditions, in particular in skin cancer
cells. Specifically, his research is focussed on signalling platforms that
regulate decision processes in cell death research (Feoktistova et al, Mol CELL
2011; Panayotova-Dimitrova et al, CELL Reports 2013) as well as the impact of
small molecule inhibitors of cell death pathways (Geserick et al, Cell Death
& Disease 2014).

The talk will be held in the Houston
Lecture Theatre at 2.00pm 5th
December 2014.

You are all very welcome to attend.

Regards, Markus Rehm

“Searching for factors that can protect pancreatic beta-cells in diabetes using biased and unbiased approaches”

Albert Lecture Theatre, 4pm, Tuesday 28th of October 2014.

James D. Johnson, Ph.D.

Oxford University Visiting Professor of Integrated Physiology, OCDEM/WTCHG,Visiting Fellow of Harris-Manchester College Associate Professor | Medicine |
Cellular and Physiological Sciences, Surgery Diabetes Research Group, Cardiovascular Research Group The University of British Columbia| Canada

Jim Johnson is Associate Professor in the
Department of Cellular and Physiological Sciences and Department of Surgery at
the University of British Columbia. He is a founding member of the Diabetes
Research Group at the Life Sciences Institute at UBC. He is Editor-in-Chief of
the journal Islets, and on the Editorial Board of Diabetes and Endocrinology.
An expert in the fundamental biology of diabetes and related conditions, he is
the author of over 93 peer-reviewed articles since 2000. His work has been
published in some of the most prestigious and highly cited journals including Cell
Metabolism, Diabetes, Diabetologia, Endocrinology, PNAS, Nature Medicine
.

 His current research focuses on multiple
themes, including: type 1 diabetes, type 2 diabetes, obesity, heart disease,
neuroscience, pancreatic cancer, and longevity. He teaches human physiology to
large and small classes and directly mentors ~12 students and 5 post-doctoral
fellows in his laboratory. The work of his team involves a multidisciplinary
approach. His work has been funded by the JDRF, the Canadian Institutes of
Health Research, the Canadian Diabetes Association, the Stem Cell Network, the
Cancer Research Society, the Canada Foundation for Innovation, and other agencies.

We are delighted to welcome Prof. Johnson to RCSI and the Centre for Systems
Medicine and all very welcome to attend,

Prof.  Jochen Prehn