Lecture entitled “NOS1AP, an adaptor protein linked to neurological diseases, reveals a novel signalling paradigm”
Venue: Albert L.T. 4pm 11th June 2015
Michael Courtney leads a research group focused on neuronal signaling mechanisms and is currently based at the Turku Centre for Biotechnology, Turku, Finland.
Research: After early investigations of the roles of
JNK signalling in neuronal death and development his group focused on
identifying targetable mechanisms by which NMDA receptor signaling influences
neuronal cell fate via activation of the p38MAPK pathway. One of the major NMDA
receptor pathways regulating p38MAPK involves the ternary complex of NMDA
receptor, PSD95 and nNOS. The lab demonstrated that PSD95/nNOS-dependent
pathways could be inhibited by nNOS-derived peptides, resulting in
neuroprotection. They showed that NMDA receptor activity leads to recruitment
of NOS1AP to nNOS and demonstrated that NOS1AP is required for NMDA-evoked
stress-activated MAPK responses and downstream excitotoxic consequences. They
developed a selective inhibitor peptide of the interaction between NOS1AP and
nNOS, with neuroprotective properties in cell cultures and in vivo (in a
preclinical model of perinatal asphyxia). More recently they identified that
interaction of nNOS with NOS1AP involves an unexpectedly complex interplay
between two distinct interaction sites. Each site is potentially druggable,
thereby providing increased opportunities for therapeutic intervention. This is
of potential interest considering that the NR-PSD95-nNOS complex and
potentially the recruitment of NOS1AP may be involved in some of the most
common causes of death and disability from stroke to neuropathic pain,
depression and anxiety disorders, while NOS1AP has been genetically linked to
schizophrenia, post-traumatic stress disorder, sudden cardiac death and long QT
All welcome to attend,
Dr. Pengyan Xia
Sox2, more than a transcription factor
Date: Thursday 30thApril 2015
The Centre for Systems Medicine is pleased to announce another speaker of our seminar series, Dr Pengyan Xia.
Dr Xia’s research is focussed on
studying development and differentiation of the haematopoietic system, in
particular in self-renewal of haematopoietic stem cells (HSCs) and anti-microbe
activity of white blood cells that derived from HSCs. Specifically, his
research is focussed on signalling platforms that regulate the
self-renewal of HSCs (Xia et al, J Exp Med 2014) as well as extracellular
DNA triggered innate immunity in neutrophils (Xia et al, Nat Immunol 2015).
You are all very welcome to attend, please register at:firstname.lastname@example.org
Centre for Systems Medicine, Department of Physiology and Medical Physics
Royal College of Surgeons in Ireland
Funded by the International Strategic Cooperation
Award (ISCA) Grant Number SFI/13/ISCA/2845 China
Innovative Approaches in Translational Melanoma Research
MEL-PLEX is a Marie Skłodoswska-Curie
Innovative Training Network funded by Horizon 2020 aiming to train a new
generation of researchers that can navigate confidently between clinical,
academic and private sector environments. As part of its training programme,
MEL-PLEX will hold a training course which will consist of workshop to provide
an overview of the current status of malignant melanoma management and the
field of translational cancer systems biology and systems medicine, followed by
a Transferable Skills course to introduce the new PhD students to basic topics
in scientific research.
The main topics addressed
pathology and treatment
proliferation and migration
cascades in melanoma
death modalities in melanoma
identification and validation
drugs and drug development
The workshop entitled “Innovative
Approaches in Translational Melanoma Research” is an open event. Deadline for
registration is April 24th 2015.
For more information and free
registration please contact: melplexETN@rcsi.ie
Venue: Cheyne Lecture Theatre, RCSI, 9am
Wednesday 6th May 2015
The Centre for
Systems Medicine is delighted to announce
distinguished speakers to its 2015 seminar series:
Prof. Donald Mager , Associate Professor of Pharmaceutical Sciences at the University at Buffalo, State University of New York (UB)
Prof.Robert Straubinger, Professor of Pharmaceutical
Sciences at University at Buffalo School of Pharmacy.
Houston Lecture Theatre, RCSI, 4.30 Pm Tuesday 10th March 2015
The Centre for Systems Medicine is delighted to announce another speaker to its 2015 seminar series:
Prof. Sergio T. Ferreira.
Professor of Biophysics,Biochemistry, and Neuroscience,
Institute of Biophysics Carlos Chagas Filho & Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio
Venue: Albert Lecture Theatre, RCSI, 9am Friday 27th February 2015
Lecture entitled: ‘”Abetaoligomers and brain inflammation link synapse failure to neuronal insulinresistance and depression in Alzheimer’s disease”
Prof. Ferreira has over 15 years extensive experience in investigating molecular and cellular mechanisms leading to synapse failure and memory loss in Alzheimer’s disease.His main research focus has been on understanding intracellular signaling pathways disrupted or altered when neurons are exposed to Ab oligomers, both in vitro and in vivo.
With particular interest in mechanisms leading to mood alterations in AD and in
shared mechanisms of pathogenesis between AD and diabetes. http://www2.bioqmed.ufrj.br/ldn/sergio.html
All very welcome to attend,
Prof. Jochen Prehn
Cancer Research – Past, Present and Future. Leading Irish and International scientists discuss how cancer research and treatment has evolved in recent years, and what the future holds.
Systems Medicine symposium, BREAST-PREDICT,Irish Cancer
Society Collaborative Cancer Research Centre marking World Cancer Day, 4th February 2015.
The Centre for
Systems Medicine is delighted to announce another speaker to its 2015 seminar
Prof. Graeme Bell
University of Chicago
Houston Lecture Theatre, RCSI, 4.30pm Thursday 22nd January 2015
entitled: ‘Genetics of Diabetes’
Dr. Bell’s research
focuses on the genetics of diabetes mellitus and the biology of the
insulin-secreting pancreatic beta-cell.
He and his colleagues
are using various genetic approaches to map and identify the genes that affect
development of type 2 diabetes mellitus as well as diabetic complications. They
carry out studies in both humans and mouse models to determine the mechanisms
by which the diabetes genes they identify affect blood glucose levels. Their
studies of pancreatic beta-cells are focused on understanding the
transcriptional regulatory networks that determine normal cell function.
All very welcome to
attend, Prof. Jochen Prehn
The Centre for Systems Medicine is pleased to announce
another speaker to our seminar series.
Dr. Maciej Dobrzynski
Systems Biology Ireland, University College Dublin, Belfield, Dublin 4
insights into population-level heterogeneity with examples of MAPK, HIF
response and ubiquitination systems
Venue: Nightingale Theatre, Thursday 15th
Jan 2015 4pm.
All welcome to attend,
Prof. Jochen Prehn
Friday 5th December 2014, at 2.00 pm
Decisions, decisions: Regulation of apoptotic and necroptotic
cell death in skin cancer
Dr Martin Leverkus
Section for Molecular Dermatology, Department of Dermatology and
Allergology, Medical Faculty Mannheim, University of Heidelberg, Germany.
The Centre for Systems Medicine is pleased to announce another speaker of our seminar series.
Dr Leverkus’s research
is focussed on studying regulation of cell death in the skin under
physiological and pathophysiological conditions, in particular in skin cancer
cells. Specifically, his research is focussed on signalling platforms that
regulate decision processes in cell death research (Feoktistova et al, Mol CELL
2011; Panayotova-Dimitrova et al, CELL Reports 2013) as well as the impact of
small molecule inhibitors of cell death pathways (Geserick et al, Cell Death
& Disease 2014).
The talk will be held in the Houston
Lecture Theatre at 2.00pm 5th
You are all very welcome to attend.
Regards, Markus Rehm
Albert Lecture Theatre, 4pm, Tuesday 28th of October 2014.
James D. Johnson, Ph.D.
Oxford University Visiting Professor of Integrated Physiology, OCDEM/WTCHG,Visiting Fellow of Harris-Manchester College Associate Professor | Medicine |
Cellular and Physiological Sciences, Surgery Diabetes Research Group, Cardiovascular Research Group The University of British Columbia| Canada
Jim Johnson is Associate Professor in the
Department of Cellular and Physiological Sciences and Department of Surgery at
the University of British Columbia. He is a founding member of the Diabetes
Research Group at the Life Sciences Institute at UBC. He is Editor-in-Chief of
the journal Islets, and on the Editorial Board of Diabetes and Endocrinology.
An expert in the fundamental biology of diabetes and related conditions, he is
the author of over 93 peer-reviewed articles since 2000. His work has been
published in some of the most prestigious and highly cited journals including Cell
Metabolism, Diabetes, Diabetologia, Endocrinology, PNAS, Nature Medicine.
His current research focuses on multiple
themes, including: type 1 diabetes, type 2 diabetes, obesity, heart disease,
neuroscience, pancreatic cancer, and longevity. He teaches human physiology to
large and small classes and directly mentors ~12 students and 5 post-doctoral
fellows in his laboratory. The work of his team involves a multidisciplinary
approach. His work has been funded by the JDRF, the Canadian Institutes of
Health Research, the Canadian Diabetes Association, the Stem Cell Network, the
Cancer Research Society, the Canada Foundation for Innovation, and other agencies.
We are delighted to welcome Prof. Johnson to RCSI and the Centre for Systems
Medicine and all very welcome to attend,
Prof. Jochen Prehn