Impaired apoptosis susceptibility is one of the key reasons for the resistance of malignant melanoma to chemo- and/or radiotherapy. So far, the understanding of apoptosis resistance or susceptibility is largely driven by descriptive and qualitative analyses of the isolated cell lines that serve as experimental models for malignant melanoma. Research at the centre aims to generate a systemic and quantitative understanding of cellular apoptosis resistance and re-sensitization of malignant melanoma.