Neurodegenerative Diseases

Cellular Bioenergetics in Neurodegenerative Diseases: A system-based pathway and target analysis: CeBioN will use computational modelling to understand common and distinct errors in energy production in various neurodegenerative disorders.

Mitochondrial dysfunctions and s and cell bioenergetics is beneficial for treatment of neurodegenerative disorders
Our aim is to elucidate common and distinct disease mechanisms in AD, PD and HD focusing on pathways regulating mitochondrial functions and cell bioenergetics and to employ computational modelling frameworks and a HTS approach developed by the partners to identify drug candidates and therapeutic targets.Mitochondrial dysfunctions and s and cell bioenergetics is beneficial for treatment of neurodegenerative disorders
Our aim is to elucidate common and distinct disease mechanisms in AD, PD and HD focusing on pathways regulating mitochondrial functions and cell bioenergetics and to employ computational modelling frameworks and a HTS approach developed by the partners to identify drug candidates and therapeutic targets. Funded by SFI: Ends 30.11-17

SFI

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The impact of hypoxia on inflammation and tumorigenesis in Ulcerative Colitis.

Hypoxia, Inflammatory Bowel Disease, Inflammation.
Ulcerative colitis (UC) is a debilitating intestinal inflammatory disorder affecting approximately 1:200 people, the prevalence of which is disproportionately high in Europe.
– Our central hypothesis is that microenvironmental hypoxia, through HIF activation, is a key determinant of inflammation and subsequent tumour development in UC patients, and that the critical link between clinical phenotype and molecular pathogenetic mechanisms can be made by computational modelling.
-Based on this hypothesis we will pursue an approach that is led by clinical features and then uses an array of experimental and theoretical models to elucidate molecular mechanisms of disease progression that will allow us (i) to assess the individual patients’ risk of UC to cancer
progression, and (ii) to design new therapies based on mechanistic systems level understanding of the pathology.
-The overall impact of this study will be to provide a demonstrator project for how systems medicine approaches can advance the personalised diagnosis and treatment of UC based on modelling the mucosal hypoxic response and predicting how this impacts upon disease progression.

 

list of collaborators

First Name Last Name Institution Country
Cormac Taylor UCD Ireland
Martin Schneider University Hospital Heidelberg Germany
Massimiliano Mazzone University of Leuven Belguim

Funded by ERACoSysMed – Ends 30-4-19

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