2020


Transcriptional CDK Inhibitors CYC065 and THZ1 Induce Apoptosis in Glioma Stem Cells Derived from Recurrent GBM.
Juric V, Düssmann H, Lamfers MLM, Prehn JHM, Rehm M, Murphy BM.Cells. 2021 May 12;10(5):1182. doi: 10.3390/cells10051182.PMID: 34066147 Free PMC article.

BCL(X)L and BCL2 increase the metabolic fitness of breast cancer cells: a single-cell imaging study.Lucantoni F, Salvucci M, Düssmann H, Lindner AU, Lambrechts D, Prehn JHM.Cell Death Differ. 2021 May;28(5):1512-1531. doi: 10.1038/s41418-020-00683-x. Epub 2020 Dec 16.PMID: 33328572

New hints towards a precision medicine strategy for IDH wild-type glioblastoma.White K, Connor K, Clerkin J, Murphy BM, Salvucci M, O’Farrell AC, Rehm M, O’Brien D, Prehn JHM, Niclou SP, Lamfers MLM, Verreault M, Idbaih A, Verhaak R, Golebiewska A, Byrne AT.Ann Oncol. 2020 Dec;31(12):1679-1692. doi: 10.1016/j.annonc.2020.08.2336. Epub 2020 Sep 9.PMID: 32918998 Free article. Review.

Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant.Fichtner M, Bozkurt E, Salvucci M, McCann C, McAllister KA, Halang L, Düssmann H, Kinsella S, Crawford N, Sessler T, Longley DB, Prehn JHM.Cell Death Dis. 2020 Nov 30;11(11):1020. doi: 10.1038/s41419-020-03232-z.PMID: 33257690 Free PMC article.


A Context-Dependent Role for MiR-124-3p on Cell Phenotype, Viability and Chemosensitivity in Neuroblastoma in vitro.
Nolan JC, Salvucci M, Carberry S, Barat A, Segura MF, Fenn J, Prehn JHM, Stallings RL, Piskareva O.Front Cell Dev Biol. 2020 Nov 20;8:559553. doi: 10.3389/fcell.2020.559553. eCollection 2020.PMID: 33330445 Free PMC article.

Systems analysis of protein signatures predicting cetuximab responses in KRAS, NRAS, BRAF and PIK3CA wild-type patient-derived xenograft models of metastatic colorectal cancer.Lindner AU, Carberry S, Monsefi N, Barat A, Salvucci M, O’Byrne R, Zanella ER, Cremona M, Hennessy BT, Bertotti A, Trusolino L, Prehn JHM.Int J Cancer. 2020 Nov 15;147(10):2891-2901. doi: 10.1002/ijc.33226. Epub 2020 Aug 13.PMID: 32700762 Free article.

Proglucagon-Derived Peptides Expression and Secretion in Rat Insulinoma INS-1 Cells.Acosta-Montalvo A, Saponaro C, Kerr-Conte J, Prehn JHM, Pattou F, Bonner C.Front Cell Dev Biol. 2020 Nov 10;8:590763. doi: 10.3389/fcell.2020.590763. eCollection 2020.PMID: 33240888 Free PMC article.

p53 upregulated mediator of apoptosis (Puma) deficiency increases survival of adult neural stem cells generated physiologically in the hippocampus, but does not protect stem cells generated in surplus after an excitotoxic lesion.Bunk EC, König HG, Prehn JHM, Kirby BP.J Basic Clin Physiol Pharmacol. 2020 Nov 9;32(2):57-66. doi: 10.1515/jbcpp-2020-0109.PMID: 33155994

Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models.O’Farrell AC, Jarzabek MA, Lindner AU, Carberry S, Conroy E, Miller IS, Connor K, Shiels L, Zanella ER, Lucantoni F, Lafferty A, White K, Meyer Villamandos MM, Dicker P, Gallagher WM, Keek SA, Sanduleanu S, Lambin P, Woodruff HC, Bertotti A, Trusolino L, Byrne AT, Prehn JHM.Cancers (Basel). 2020 Oct 14;12(10):2978. doi: 10.3390/cancers12102978.PMID: 33066609 Free PMC article.

Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy.Brennan GP, Bauer S, Engel T, Jimenez-Mateos EM, Del Gallo F, Hill TDM, Connolly NMC, Costard LS, Neubert V, Salvetti B, Sanz-Rodriguez A, Heiland M, Mamad O, Brindley E, Norwood B, Batool A, Raoof R, El-Naggar H, Reschke CR, Delanty N, Prehn JHM, Fabene P, Mooney C, Rosenow F, Henshall DC.Neurobiol Dis. 2020 Oct;144:105048. doi: 10.1016/j.nbd.2020.105048. Epub 2020 Aug 13.PMID: 32800995 Free article.

The apoptosome molecular timer synergises with XIAP to suppress apoptosis execution and contributes to prognosticating survival in colorectal cancer.Fullstone G, Bauer TL, Guttà C, Salvucci M, Prehn JHM, Rehm M.Cell Death Differ. 2020 Oct;27(10):2828-2842. doi: 10.1038/s41418-020-0545-9. Epub 2020 Apr 27.PMID: 32341447 Free PMC article.

Evaluation of an aldo-keto reductase gene signature with prognostic significance in colon cancer via activation of epithelial to mesenchymal transition and the p70S6K pathway.Demirkol Canlı S, Seza EG, Sheraj I, Gömçeli I, Turhan N, Carberry S, Prehn JHM, Güre AO, Banerjee S.Carcinogenesis. 2020 Sep 24;41(9):1219-1228. doi: 10.1093/carcin/bgaa072.PMID: 32628753

Microsatellite instability and response to neoadjuvant chemoradiotherapy in rectal cancer: A systematic review and meta-analysis.O’Connell E, Reynolds IS, McNamara DA, Prehn JHM, Burke JP.Surg Oncol. 2020 Sep;34:57-62. doi: 10.1016/j.suronc.2020.03.009. Epub 2020 Apr 2.PMID: 32891354

Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.Wang H, Wang N, Xu D, Ma Q, Chen Y, Xu S, Xia Q, Zhang Y, Prehn JHM, Wang G, Ying Z.Autophagy. 2020 Sep;16(9):1683-1696. doi: 10.1080/15548627.2019.1704104. Epub 2019 Dec 18.PMID: 31826695 Free PMC article.

5’ValCAC tRNA fragment generated as part of a protective angiogenin response provides prognostic value in amyotrophic lateral sclerosis.Hogg MC, Rayner M, Susdalzew S, Monsefi N, Crivello M, Woods I, Resler A, Blackbourn L, Fabbrizio P, Trolese MC, Nardo G, Bendotti C, van den Berg LH, van Es MA, Prehn JHM.Brain Commun. 2020 Aug 28;2(2):fcaa138. doi: 10.1093/braincomms/fcaa138. eCollection 2020.PMID: 33543130 Free PMC article.

Mucinous Adenocarcinoma of the Rectum: A Whole Genome Sequencing Study.Reynolds IS, Thomas V, O’Connell E, Fichtner M, McNamara DA, Kay EW, Prehn JHM, Burke JP, Furney SJ.Front Oncol. 2020 Aug 26;10:1682. doi: 10.3389/fonc.2020.01682. eCollection 2020.PMID: 32984045 Free PMC article.

A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy.Venø MT, Reschke CR, Morris G, Connolly NMC, Su J, Yan Y, Engel T, Jimenez-Mateos EM, Harder LM, Pultz D, Haunsberger SJ, Pal A, Heller JP, Campbell A, Langa E, Brennan GP, Conboy K, Richardson A, Norwood BA, Costard LS, Neubert V, Del Gallo F, Salvetti B, Vangoor VR, Sanz-Rodriguez A, Muilu J, Fabene PF, Pasterkamp RJ, Prehn JHM, Schorge S, Andersen JS, Rosenow F, Bauer S, Kjems J, Henshall DC.Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15977-15988. doi: 10.1073/pnas.1919313117. Epub 2020 Jun 24.PMID: 32581127 Free PMC article.

Combination of variations in inflammation- and endoplasmic reticulum-associated genes as putative biomarker for bevacizumab response in KRAS wild-type colorectal cancer.Barat A, Smeets D, Moran B, Zhang W, Cao S, Das S, Klinger R, Betge J, Murphy V, Bacon O, Kay EW, Van Grieken NCT, Verheul HMW, Gaiser T, Schulte N, Ebert MP, Fender B, Hennessy BT, McNamara DA, O’Connor D, Gallagher WM, Cremolini C, Loupakis F, Parikh A, Mancao C, Ylstra B, Lambrechts D, Lenz HJ, Byrne AT, Prehn JHM.Sci Rep. 2020 Jun 17;10(1):9778. doi: 10.1038/s41598-020-65869-2.PMID: 32555399 Free PMC article.

AMPK Preferentially Depresses Retrograde Transport of Axonal Mitochondria during Localized Nutrient Deprivation.Watters O, Connolly NMC, König HG, Düssmann H, Prehn JHM.J Neurosci. 2020 Jun 17;40(25):4798-4812. doi: 10.1523/JNEUROSCI.2067-19.2020. Epub 2020 May 11.PMID: 32393534 Free PMC article.

Mucinous adenocarcinoma is a pharmacogenomically distinct subtype of colorectal cancer.Reynolds IS, O’Connell E, Fichtner M, McNamara DA, Kay EW, Prehn JHM, Furney SJ, Burke JP.Pharmacogenomics J. 2020 Jun;20(3):524-532. doi: 10.1038/s41397-019-0137-6. Epub 2019 Dec 10.PMID: 31819162 Review.

Vascular regression precedes motor neuron loss in the FUS (1-359) ALS mouse model. Crivello M, Hogg MC, Jirström E, Halang L, Woods I, Rayner M, Coughlan KS, Lewandowski SA, Prehn JHM.Dis Model Mech. 2020 May 15;13(5):dmm045310. doi: 10.1242/dmm.045310.PMID: 32482632 Free PMC article. No abstract available.

Quantification of tRNA fragments by electrochemical direct detection in small volume biofluid samples.McArdle H, Hogg MC, Bauer S, Rosenow F, Prehn JHM, Adamson K, Henshall DC, Spain E.Sci Rep. 2020 May 5;10(1):7516. doi: 10.1038/s41598-020-64485-4.PMID: 32371908 Free PMC article.

Angiogenin and tRNA fragments in Parkinson’s disease and neurodegeneration.Prehn JHM, Jirström E.Acta Pharmacol Sin. 2020 Apr;41(4):442-446. doi: 10.1038/s41401-020-0375-9. Epub 2020 Mar 6.PMID: 32144338 Free PMC article. Review.

C9orf72 associates with inactive Rag GTPases and regulates mTORC1-mediated autophagosomal and lysosomal biogenesis.Wang M, Wang H, Tao Z, Xia Q, Hao Z, Prehn JHM, Zhen X, Wang G, Ying Z.Aging Cell. 2020 Apr;19(4):e13126. doi: 10.1111/acel.13126. Epub 2020 Feb 25.PMID: 32100453 Free PMC article.

Precision Therapy in RAS Mutant Colorectal Cancer.Dienstmann R, Connor K, Byrne AT; COLOSSUS Consortium.Gastroenterology. 2020 Mar;158(4):806-811. doi: 10.1053/j.gastro.2019.12.051. Epub 2020 Jan 21.PMID: 31972237 No abstract available.

Loss of angiogenin function is related to earlier ALS onset and a paradoxical increase in ALS duration.Aluri KC, Salisbury JP, Prehn JHM, Agar JN.Sci Rep. 2020 Feb 28;10(1):3715. doi: 10.1038/s41598-020-60431-6.PMID: 32111867 Free PMC article.


Mucin Pools Following Neoadjuvant Chemoradiotherapy for Rectal Cancer: A Marker of Response or Epiphenomenon?
Reynolds IS, O’Connell E, Fichtner M, Kay EW, McNamara DA, Prehn JHM, Burke JP.Am J Surg Pathol. 2020 Feb;44(2):280-287. doi: 10.1097/PAS.0000000000001373.PMID: 31567193


Circulating miR-330-3p in Late Pregnancy is Associated with Pregnancy Outcomes Among Lean Women with GDM.
Pfeiffer S, Sánchez-Lechuga B, Donovan P, Halang L, Prehn JHM, Campos-Caro A, Byrne MM, López-Tinoco C.Sci Rep. 2020 Jan 22;10(1):908. doi: 10.1038/s41598-020-57838-6.PMID: 31969632 Free PMC article.

Systems biology analysis identifies molecular determinants of chemotherapy-induced diarrhoea.Lindner AU, Resler AJ, Carberry S, Oficjalska K, Bacon O, Lee CS, Choudhry A, Burke JP, Sheahan K, Cremona M, Hennessy BT, McNamara D, Doherty G, Ryan EJ, Prehn JHM.J Mol Med (Berl). 2020 Jan;98(1):149-159. doi: 10.1007/s00109-019-01864-z. Epub 2019 Dec 17.PMID: 31848663