Colossus Publications:

Dienstmann R1, Connor K2, Byrne AT2; COLOSSUS Consortium. Fridman WH, Lambrechts D, Sadanandam A, Trusolino L, Prehn JHM, Tabernero J, Kolch W. Precision Therapy in RAS Mutant Colorectal Cancer  2020 Mar;158(4):806-811. doi: 10.1053/j.gastro.2019.12.051. Epub 2020 Jan 21. Download the pdf here

Russo et al. Adaptive mutability of colorectal cancers in response to targeted therapies. Science 2019 Nov 7. pii: eaav4474. DOI: 10.1126/science.aav4474. Download the pdf here.

Irene Catalano, Elena Grassi, Andrea Bertotti, Livio Trusolino, Immunogenomics of Colorectal Tumors: Facts and Hypotheses on an Evolving Saga, Trends in Cancer, December 2019, Vol. 5, No. 12 DOI: https://doi.org/10.1016/j.trecan.2019.10.006. Download the pdf here.

WH Fridman, I Miller, C Sautès-Fridman, AT Byrne, Therapeutic Targeting of the Colorectal Tumor Stroma, Gastroenterology, 14 October 2019, pii: S0016-5085(19)41442-X. DOI: 10.1053/j.gastro.2019.09.045 [Epub ahead of print].

Elke Burgermeister, Francesca Battaglin, Fagr Eladly, Wen Wu, Frank Herweck , Nadine Schulte, Johannes Betge, Nicolai Härtel, Jakob N. Kather, Cleo-Aron Weis, Timo Gaiser, Alexander Marx, Christel Weiss, Ralf Hofheinz, Ian S. Miller, Fotios Loupakis, Heinz-Josef Lenz, Annette T. Byrne, Matthias P. Ebert, Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor A,  2019 Jul;45:139-154. DOI: 10.1016/j.ebiom.2019.07.004. Epub 2019 Jul Download the pdf here.

Irene Catalano and Livio Trusolino, The Stromal and Immune Landscape of Colorectal Cancer Progression during Anti-EGFR Therapy, Cancer Cell, Volume 36, Issue 1, 8 July 2019, Pages 1-3, DOI: 10.1016/j.ccell.2019.06.001. Embargo until 01/08/2020.

Caterina Thomaseth, Dirk Fey, Tapesh Santra, Oleksii S. Rukhlenko, Nicole E. Radde, and Boris N. Kholodenko, Impact of measurement noise, experimental design, and estimation methods on Modular Response Analysis based network reconstruction, Sci Rep. 2018; 8: 16217. Published online 2018 Nov 1. DOI: 10.1038/s41598-018-34353-3  Download the pdf here.

O’Farrell AC, Miller IS, Evans R, Alamanou M, Cary M, Mallya Udupi G, Lafferty A, Monsefi N, Cremona M, Prehn JHM, Verheul HM, Gallagher WM, Gehrmann M, Byrne AT, Implementing Reverse Phase Protein Array Profiling as a Sensitive Method for the Early Pre-Clinical Detection of Off-Target Toxicities Associated with Sunitinib Malate, 2019 Feb 15:e1800159. DOI: 10.1002/prca.201800159. Embargoed until 15 February 2020. Repository link: https://epubs.rcsi.ie/physiolart/162/

Florent Petitprez, Cheng-Ming Sun, Laetitia Lacroix, Catherine Sautès-Fridman, Aurélien de Reyniès and Wolf H. Fridman, Quantitative analyses of the tumor microenvironment composition and orientation in the era of precision medicine, Frontiers in Oncology, September 25, 2018, DOI: 10.3389/fonc.2018.00390. Download the pdf here.

M. Sturrock, I. S. Miller, G. Kang, N. Hannis Arba’ie, A. C. O’Farrell, A. Barat, G. Marston, P. L. Coletta, A. T. Byrne, J. H. Prehn,  Anti-angiogenic drug scheduling optimisation with application to colorectal cancer, Scientific Reports, V 8, Article number: 11182 (2018).  DOI: 10.1038/s41598-018-29318-5  Download the pdf here.

Mucinous Adenocarcinoma Publications

Mucinous adenocarcinoma is a pharmacogenomically distinct subtype of colorectal cancer.

Reynolds IS, O’Connell E, Fichtner M, McNamara DA, Kay EW, Prehn JHM, Furney SJ, Burke JP. Pharmacogenomics J. 2019 Dec 10. doi: 10.1038/s41397-019-0137-6.  PMID:31819162

Mucinous adenocarcinoma of the colon and rectum: A genomic analysis.

Reynolds IS, O’Connell E, Fichtner M, McNamara DA, Kay EW, Prehn JHM, Furney SJ, Burke JP. J Surg Oncol. 2019 Dec;120(8):1427-1435. doi: 10.1002/jso.25764. Epub 2019 Nov 14. PMID: 31729037

Mucin Pools Following Neoadjuvant Chemoradiotherapy for Rectal Cancer: A Marker of Response or Epiphenomenon?

Reynolds IS, O’Connell E, Fichtner M, Kay EW, McNamara DA, Prehn JHM, Burke JP. Am J Surg Pathol. 2020 Feb;44(2):280-287. doi: 10.1097/PAS.0000000000001373. PMID: 31567193

Meta-analysis of the molecular associations of mucinous colorectal cancer.

Reynolds IS, Furney SJ, Kay EW, McNamara DA, Prehn JHM, Burke JP. Br J Surg. 2019 May;106(6):682-691. doi: 10.1002/bjs.11142. Epub 2019 Apr 4. PMID: 30945755

Mucin glycoproteins block apoptosis; promote invasion, proliferation, and migration; and cause chemoresistance through diverse pathways in epithelial cancers. Reynolds IS, Fichtner M, McNamara DA, Kay EW, Prehn JHM, Burke JP. Cancer Metastasis Rev. 2019 Jun;38(1-2):237-257. doi: 10.1007/s10555-019-09781-w. PMID: 30680581

Colofortell Publications

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models. Meehan TF, Conte N, Goldstein T, Inghirami G, Murakami MA, Brabetz S, Gu Z, Wiser JA, Dunn P, Begley DA, Krupke DM, Bertotti A, Bruna A, Brush MH, Byrne AT, Caldas C, Christie AL, Clark DA, Dowst H, Dry JR, Doroshow JH, Duchamp O, Evrard YA, Ferretti S, Frese KK, Goodwin NC, Greenawalt D, Haendel MA, Hermans E, Houghton PJ, Jonkers J, Kemper K, Khor TO, Lewis MT, Lloyd KCK, Mason J, Medico E, Neuhauser SB, Olson JM, Peeper DS, Rueda OM, Seong JK, Trusolino L, Vinolo E, Wechsler-Reya RJ, Weinstock DM, Welm A, Weroha SJ, Amant F, Pfister SM, Kool M, Parkinson H, Butte AJ, Bult CJ. Cancer Res. 2017 Nov 1;77(21):e62-e66. doi: 10.1158/0008-5472.CAN-17-0582.PMID: 29092942

Interrogating open issues in cancer medicine with patient-derived xenografts.   Byrne AT, Alférez DG, Amant F, Annibali D, Arribas J, Biankin AV, Bruna A, Budinská E, Caldas C, Chang DK, Clarke RB, Clevers H, Coukos G, Dangles-Marie V, Eckhardt SG, Gonzalez-Suarez E, Hermans E, Hidalgo M, Jarzabek MA, de Jong S, Jonkers J, Kemper K, Lanfrancone L, Mælandsmo GM, Marangoni E, Marine JC, Medico E, Norum JH, Palmer HG, Peeper DS, Pelicci PG, Piris-Gimenez A, Roman-Roman S, Rueda OM, Seoane J, Serra V, Soucek L, Vanhecke D, Villanueva A, Vinolo E, Bertotti A, Trusolino L.  Nat Rev Cancer. 2017 Sep 15;17(10):632. doi: 10.1038/nrc.2017.85. [Epub ahead of print] PMID: 28912576

Interrogating open issues in cancer precision medicine with patient-derived xenografts.  Byrne AT, Alférez DG, Amant F, Annibali D, Arribas J, Biankin AV, Bruna A, Budinská E, Caldas C, Chang DK, Clarke RB, Clevers H, Coukos G, Dangles-Marie V, Eckhardt SG, Gonzalez-Suarez E, Hermans E, Hidalgo M, Jarzabek MA, de Jong S, Jonkers J, Kemper K, Lanfrancone L, Mælandsmo GM, Marangoni E, Marine JC, Medico E, Norum JH, Palmer HG, Peeper DS, Pelicci PG, Piris-Gimenez A, Roman-Roman S, Rueda OM, Seoane J, Serra V, Soucek L, Vanhecke D, Villanueva A, Vinolo E, Bertotti A, Trusolino L. Nat Rev Cancer. 2017 Apr;17(4):254-268. doi: 10.1038/nrc.2016.140. Epub 2017 Jan 20. Review. Erratum in: Nat Rev Cancer. 2017 Sep 15; PMID: 28104906

Patient-derived xenograft models: an emerging platform for translational cancer research.  Hidalgo M, Amant F, Biankin AV, Budinská E, Byrne AT , Caldas C, Clarke RB, de Jong S, Jonkers J, Mælandsmo GM, Roman-Roman S, Seoane J , Trusolino L , Villanueva A. Cancer Discov. 2014 Sep;4(9):998-1013. doi: 10.1158/2159-8290.CD-14-0001. Epub 2014 Jul 15. Review. PMID: 2518519

OxyUc Publications

 Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation. Kinsella S1,2, Fichtner M1, Watters O1, König HG1, Prehn JHM 2018 May 2;15(1):130. doi: 10.1186/s12974-018-1143-3