Publications

2014 – 2013 – 2012 – 2011 – 2010 – 2009 – 2008 – 2007 – 2006 – 2005 – 2003 – and earlier

2018

• Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy.

  Raoof R, Bauer S, El Naggar H, Connolly NMC, Brennan GP, Brindley E, Hill T, McArdle H, Spain E, Forster RJ, Prehn JHM, Hamer H, Delanty N, Rosenow F, Mooney C, Henshall DC.EBioMedicine. 2018 Dec;38:127-141. doi: 10.1016/j.ebiom.2018.10.068. Epub 2018 Nov 2.PMID:30396857

• Radiation-Induced Gliomas. Aherne NJ, Murphy BM. Crit Rev Oncog. 2018;23(1-2):113-118. doi: 10.1615/CritRevOncog.2018025740. PMID: 29953370

• Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711. Crawford N, Salvucci M, Hellwig CT, Lincoln FA, Mooney RE, O’Connor CL, Prehn JH, Longley DB, Rehm M. Cell Death Differ. 2018 Nov;25(11):1952-1966. doi: 10.1038/s41418-018-0082-y. Epub 2018 Mar 2.PMID: 29500433
• Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism. Lincoln FA, Imig D, Boccellato C, Juric V, Noonan J, Kontermann RE, Allgöwer F, Murphy BM, Rehm M. Cell Death Dis. 2018 Nov 1;9(11):1112. doi: 10.1038/s41419-018-1160-2. PMID: 3038573

• Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy.  Raoof R, Bauer S, El Naggar H, Connolly NMC, Brennan GP, Brindley E, Hill T, McArdle H, Spain E, Forster RJ, Prehn JHM, Hamer H, Delanty N, Rosenow F, Mooney C, Henshall DC. EBioMedicine. 2018 Nov 2. pii: S2352-3964(18)30489-4. doi: 10.1016/j.ebiom.2018.10.068. [Epub ahead of print]PMID: 30396857

• Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy. Smeets D, Miller IS, O’Connor DP, Das S, Moran B, Boeckx B, Gaiser T, Betge J, Barat A, Klinger R, van Grieken NCT, Cremolini C, Prenen H, Mazzone M, Depreeuw J, Bacon O, Fender B, Brady J, Hennessy BT, McNamara DA, Kay E, Verheul HM, Maarten N, Gallagher WM, Murphy V, Prehn JHM, Koopman M, Punt CJA, Loupakis F, Ebert MPA, Ylstra B, Lambrechts D, Byrne AT. Nat Commun. 2018 Oct 5;9(1):4112. doi: 10.1038/s41467-018-06567-6. PMID:30291241

• ER stress signaling has an activating transcription factor 6α (ATF6)-dependent “off-switch”. Walter F, O’Brien A, Concannon CG, Düssmann H, Prehn JHM.J Biol Chem. 2018 Nov 23;293(47):18270-18284. doi: 10.1074/jbc.RA118.002121. Epub 2018 Oct 4.PMID: 30287689

• Metabolic Targeting of Breast Cancer Cells With the 2-Deoxy-D-Glucose and the Mitochondrial Bioenergetics Inhibitor MDIVI-1.Lucantoni F, Dussmann H, Prehn JHM. Front Cell Dev Biol. 2018 Sep 11;6:113. doi: 10.3389/fcell.2018.00113. eCollection 2018. PMID: 30255019

• Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers. Lindner AU, Lucantoni F, Varešlija D, Resler A, Murphy BM, Gallagher WM, Hill ADK, Young LS, Prehn JHM. J Mol Med (Berl). 2018 Oct;96(10):1025-1037. doi: 10.1007/s00109-018-1675-0. Epub 2018 Aug 1. PMID: 30069746

• Metabolic Targeting of Breast Cancer Cells With the 2-Deoxy-D-Glucose and the Mitochondrial Bioenergetics Inhibitor MDIVI-1. Lucantoni F, Dussmann H, Prehn JHM. Front Cell Dev Biol. 2018 Sep 11;6:113. doi: 10.3389/fcell.2018.00113. eCollection 2018. PMID: 30255019

• Anti-angiogenic drug scheduling optimisation with application to colorectal cancer. Sturrock M, Miller IS, Kang G, Hannis Arba’ie N, O’Farrell AC, Barat A, Marston G, Coletta PL, Byrne AT, Prehn JH. Sci Rep. 2018 Jul 25;8(1):11182. doi: 10.1038/s41598-018-29318-5. Erratum in: Sci Rep. 2018 Sep 27;8(1):14705.PMID:30046049

• Complex spectrum of phenobarbital effects in a mouse model of neonatal hypoxia-induced seizures. Quinlan SMM, Rodriguez-Alvarez N, Molloy EJ, Madden SF, Boylan GB, Henshall DC, Jimenez-Mateos EM.Sci Rep. 2018 Jul 3;8(1):9986. doi: 10.1038/s41598-018-28044-2. PMID:29968748

• Interrogation of transcriptomic changes associated with drug-induced hepatic sinusoidal dilatation in colorectal cancer. Jarzabek MA, Proctor WR, Vogt J, Desai R, Dicker P, Cain G, Raja R, Brodbeck J, Stevens D, van der Stok EP, Martens JWM, Verhoef C, Hegde PS, Byrne AT, Tarrant JM.PLoS One. 2018 Jun 7;13(6):e0198099. doi: 10.1371/journal.pone.0198099. eCollection 2018. PMID: 29879147

• BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose. Lucantoni F, Düssmann H, Llorente-Folch I, Prehn JHM.Oncotarget. 2018 May 25;9(40):26046-26063. doi 10.18632/oncotarget.25433. eCollection 2018 May 25.PMID: 29899841

• Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab. van Dijk E, Biesma HD, Cordes M, Smeets D, Neerincx M, Das S, Eijk PP, Murphy V, Barat A, Bacon O, Prehn JHM, Betge J, Gaiser T, Fender B, Meijer GA, McNamara DA, Klinger R, Koopman M, Ebert MPA, Kay EW, Hennessey BT, Verheul HMW, Gallagher WM, O’Connor DP, Punt CJA, Loupakis F, Lambrechts D, Byrne AT, van Grieken NCT, Ylstra B. J Clin Oncol. 2018 Jul 10;36(20):2052-2060. doi: 10.1200/JCO.2017.77.1782. Epub 2018 May 24. PMID: 29792754
• Kinsella S, Fichtner M, Watters O, König HG, Prehn JHM. Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation.  J Neuroinflammation. 2018 May 2;15(1):130. doi: 10.1186/s12974-018-1143-3.

  PMID: 29720226

• Bano D, Prehn JHM. Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer. EBioMedicine. 2018 Apr;30:29-37. doi: 10.1016/j.ebiom.2018.03.016. Epub 2018 Mar 23. Review. PMID: 29605508
• Crivello M, O’Riordan SL, Woods I, Cannon S, Halang L, Coughlan KS, Hogg MC, Lewandowski SA, Prehn JHM. Pleiotropic activity of systemically delivered angiogenin in the SOD1^G93A mouse model. Neuropharmacology. 2018 May 1;133:503-511. doi: 10.1016/j.neuropharm.2018.02.022. Epub 2018 Feb 25. PMID: 29486168
• Carberry S, D’Orsi B, Monsefi N, Salvucci M, Bacon O, Fay J, Rehm M, McNamara D, Kay EW, Prehn JHM. The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer. Cell Death Dis. 2018 Jan 26;9(2):125. doi: 10.1038/s41419-017-0140-2.

• Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D’Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.  Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review. PMID: 29362479
• Lucantoni F, Lindner AU, O’Donovan N, Düssmann H, Prehn JHM. Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells. Cell Death Dis. 2018 Jan 19;9(2):42. doi: 10.1038/s41419-017-0039-y.

  PMID: 29352235

  2017

• Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordán J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, Pozzan T, Rizzuto R, Satrústegui J, Slack RS, Swanson RA, Swerdlow RH, Will Y, Ying Z, Joselin A, Gioran A, Moreira Pinho C, Watters O, Salvucci M, Llorente-Folch I, Park DS, Bano D, Ankarcrona M, Pizzo P, Prehn JHM. Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases. Cell Death Differ. 2018 Mar;25(3):542-572. doi: 10.1038/s41418-017-0020-4. Epub 2017 Dec 11. Review. PMID: 29229998

• Hogg MC, Halang L, Woods I, Coughlan KS, Prehn JHM.Hogg MC, Halang L, Woods I, Coughlan KS, Prehn JHM.Riluzole does not improve lifespan or motor function in three ALS mouse models.Amyotroph Lateral Scler Frontotemporal Degener. 2017 Dec 8:1-8. doi: 10.1080/21678421.2017.1407796. [Epub ahead of print]PMID: 29221425

• Anilkumar U, Weisova P, Schmid J, Bernas T, Huber HJ, Düssmann H, Connolly NMC, Prehn JHM. Defining external factors that determine neuronal survival, apoptosis and necrosis during excitotoxic injury using a high content screening imaging platform.
• González JA, Prehn JHM. Orexin-A/hypocretin-1 immunoreactivity in the lateral hypothalamus is reduced in genetically obese but not in diet-induced obese mice. Neuroscience. 2017 Nov 9. pii: S0306-4522(17)30796-0. doi: 10.1016/j.neuroscience.2017.11.009. PMID: 29129795

• Meehan TF, Conte N, Goldstein T, Inghirami G, Murakami MA, Brabetz S, Gu Z, Wiser JA, Dunn P, Begley DA, Krupke DM, Bertotti A, Bruna A, Brush MH, Byrne AT, Caldas C, Christie AL, Clark DA, Dowst H, Dry JR, Doroshow JH, Duchamp O, Evrard YA, Ferretti S, Frese KK, Goodwin NC, Greenawalt D, Haendel MA, Hermans E, Houghton PJ, Jonkers J, Kemper K, Khor TO, Lewis MT, Lloyd KCK, Mason J, Medico E, Neuhauser SB, Olson JM, Peeper DS, Rueda OM, Seong JK, Trusolino L, Vinolo E, Wechsler-Reya RJ, Weinstock DM, Welm A, Weroha SJ, Amant F, Pfister SM, Kool M, Parkinson H, Butte AJ, Bult CJ. PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models. Cancer Res. 2017 Nov 1;77(21):e62-e66. doi: 10.1158/0008-5472.CAN-17-0582. PMID: 29092942

• König HG, Watters O, Kinsella S, Ameen M, Fenner BJ, Prehn JHM. A constitutively-active IKK-complex at the axon initial segment. Brain Res. 2017 Oct 24. pii: S0006-8993(17)30478-X. doi: 10.1016/j.brainres.2017.10.020. [Epub ahead of print; PMID: 29079505

•  Byrne AT, Alférez DG, Amant F, Annibali D, Arribas J, Biankin AV, Bruna A, Budinská E, Caldas C, Chang DK, Clarke RB, Clevers H, Coukos G, Dangles-Marie V, Eckhardt SG, Gonzalez-Suarez E, Hermans E, Hidalgo M, Jarzabek MA, de Jong S, Jonkers J, Kemper K, Lanfrancone L, Mælandsmo GM, Marangoni E, Marine JC, Medico E, Norum JH, Palmer HG, Peeper DS, Pelicci PG, Piris-Gimenez A, Roman-Roman S, Rueda OM, Seoane J, Serra V, Soucek L, Vanhecke D, Villanueva A, Vinolo E, Bertotti A, Trusolino L. Interrogating open issues in cancer medicine with patient-derived xenografts. Nat Rev Cancer. 2017 Sep 15;17(10):632. doi: 10.1038/nrc.2017.85. [Epub ahead of print] PMID: 28912576

• Moran B, Das S, Smeets D, Peutman G, Klinger R, Fender B, Connor K, Ebert M, Gaiser T, Prehn JH, Bacon O, Kay E, Hennessy B, Murphy V, Ylstra B, Lambrechts D, Byrne AT, Gallagher WM, O’Connor DP. Assessment of concordance between fresh-frozen and formalin-fixed paraffin embedded tumor DNA methylation using a targeted sequencing approach.  Oncotarget. 2017 Jul 18;8(29):48126-48137. doi: 10.18632/oncotarget.18296. PMID: 28611295

• Cerebrospinal fluid microRNAs are potential biomarkers of temporal lobe epilepsy and status epilepticus. Raoof R, Jimenez-Mateos EM, Bauer S, Tackenberg B, Rosenow F, Lang J, Onugoren MD, Hamer H, Huchtemann T, Körtvélyessy P, Connolly NMC, Pfeiffer S, Prehn JHM, Farrell MA, O’Brien DF, Henshall DC, Mooney C. Sci Rep. 2017 Jun 12;7(1):3328. doi: 10.1038/s41598-017-02969-6. PMID: 28607431

•  Düssmann H, Perez-Alvarez S, Anilkumar U, Papkovsky DB, Prehn JH. Single-cell time-lapse imaging of intracellular O₂ in response to metabolic inhibition and mitochondrial cytochrome-c release.Cell Death Dis. 2017 Jun 1;8(6):e2853. doi: 10.1038/cddis.2017.247. PMID: 28569778

•  Zuurbier L, Rahman A, Cordes M, Scheick J, Wong TJ, Rustenburg F, Joseph JC, Dynoodt P, Casey R, Drillenburg P, Gerhards M, Barat A, Klinger R, Fender B, O’Connor DP, Betge J, Ebert MP, Gaiser T, Prehn JHM, Griffioen AW, van Grieken NCT, Ylstra B, Byrne AT, van der Flier LG, Gallagher WM, Postel R. Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer.Oncotarget. 2017 Jun 27;8(26):42949-42961. doi: 10.18632/oncotarget.17306. PMID:28487489

• Control of mitochondrial physiology and cell death by the Bcl-2 family proteins Bax and Bok. D’Orsi B, Mateyka J, Prehn JH.Neurochem Int. 2017 Mar 15. pii: S0197-0186(17)30036-0. doi: 10.1016/j.neuint.2017.03.010. [Epub ahead of print]PMID:28315370

• Time-lapse imaging of p65 and IκBα translocation kinetics following Ca₂₊-induced neuronal injury reveals biphasic translocation kinetics in surviving neurons. Schwamborn R, Düssmann H, König HG, Prehn JHM. Mol Cell Neurosci. 2017 Apr;80:148-158. doi: 10.1016/j.mcn.2017.02.007. Epub 2017 Feb 24. PMID:28238890

• Beyond the exome: the role of non-coding somatic mutations in cancer.Piraino SW, Furney SJ.Ann Oncol. 2016 Feb;27(2):240-8. doi: 10.1093/annonc/mdv561. Epub 2015 Nov 23. Review.PMID: 26598542

• Identification of coding and non-coding mutational hotspots in cancer genomes.Piraino SW, Furney SJ.BMC Genomics. 2017 Jan 5;18(1):17. doi: 10.1186/s12864-016-3420-9.PMID: 28056774
• Control of mitochondrial physiology and cell death by the Bcl-2 family proteins Bax and Bok. D’Orsi B, Mateyka J, Prehn JH. Neurochem Int. 2017 Mar 15. pii: S0197-0186(17)30036-0. doi: 10.1016/j.neuint.2017.03.010. PMID: 28315370
• Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells. Tivnan A, Heilinger T, Ramsey JM, O’Connor G, Pokorny JL, Sarkaria JN, Stringer BW, Day BW, Boyd AW, Kim EL, Lode HN, Cryan SA, Prehn JH.Oncotarget. 2017 Mar 7;8(10):16605-16620. doi: 10.18632/oncotarget.15073.PMID:28178667
• miRNAmeConverter: an R/bioconductor package for translating mature miRNA names to different miRBase versions. Haunsberger SJ, Connolly NM, Prehn JH. Bioinformatics. 2017 Feb 15;33(4):592-593. doi: 10.1093/bioinformatics/btw660.

• König HG, Schwamborn R, Andresen S, Kinsella S, Watters O, Fenner B, Prehn JH. NF-κB regulates neuronal ankyrin-G via a negative feedback loop. Sci Rep. 2017 Feb 9;7:42006. doi: 10.1038/srep42006.

• Ichikawa N, Alves M, Pfeiffer S, Langa E, Hernández-Santana YE, Suzuki H, Prehn JH, Engel T, Henshall DC . Deletion of the BH3-only protein Noxa alters electrographic seizures but does not protect against hippocampal damage after status epilepticus in mice. Cell Death Dis. 2017 Jan 12;8(1):e2556. doi: 10.1038/cddis.2016.301.PMID:28079889
• Tivnan A¹, Heilinger T^2,3, Lavelle EC^4,5,6, Prehn JH². Advances in Immunotherapy for the treatment of Neurobalstoma: Journal of Neoru-Oncology 2016,Oct 14 PMID:27743144
  • • 2016 
      • Salvucci M, Würstle ML, Morgan C, Curry S, Cremona M, Lindner AU, Bacon O, Resler AJ, Murphy AC, O’Byrne R, Flanagan L, Dasgupta S, Rice N, Pilati C, Zink E, Schöller LM, Toomey S, Lawler M, Johnston PG, Wilson RH, Camilleri-Broët S, Salto-Tellez M, McNamara DA, Kay EW, Laurent-Puig P, Van Schaeybroeck S, Hennessy BT, Longley DB, Rehm M, Prehn JH. A stepwise integrated approach to personalized risk predictions in stage III colorectal cancer. Clin Cancer Res. 2016 Sep 20. PMID:27649552
      • Lindner AU, Salvucci M, Morgan C, Monsefi N, Resler AJ, Cremona M, Curry S, Toomey S, O’Byrne R, Bacon O, Stühler M, Flanagan L, Wilson R, Johnston PG, Salto-Tellez M, Camilleri-Broët S, McNamara DA, Kay EW, Hennessy BT, Laurent-Puig P, Van Schaeybroeck S, Prehn JH. BCL-2 system analysis identifies high-risk colorectal cancer patients. Gut. 2016 Sep 23. PMID: 27663504
      • Ryan D, Carberry S, Murphy ÁC, Lindner AU, Fay J, Hector S, McCawley N, Bacon O, Concannon CG, Kay EW, McNamara DA, Prehn JH. Calnexin, an ER-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer. J Transl Med. 2016 Jul 1;14(1):196. PMID: 27369741
      • Boland K, Flanagan L, McCawley N, Pabari R, Kay EW, McNamara DA, Murray F, Byrne AT, Ramtoola Z, Concannon CG, Prehn JH. Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer. Eur J Pharmacol. 2016 Mar 17. pii: S0014-2999(16)30153-4. [Epub ahead of print] PMID: 26997367
      • Martin NA, Bonner H, Elkjær ML, D’Orsi B, Chen G, König HG, Svensson M, Deierborg T, Pfeiffer S, Prehn JH, Lambertsen KL. BID Mediates Oxygen-Glucose Deprivation-Induced Neuronal Injury in Organotypic Hippocampal Slice Cultures and Modulates Tissue Inflammation in a Transient Focal Cerebral Ischemia Model without Changing Lesion Volume. Front Cell Neurosci. 2016 Feb 3;10:14. eCollection 2016. PMID: 26869884.
      • Flanagan L, Meyer M, Fay J, Curry S, Bacon O, Duessmann H, John K, Boland KC, McNamara DA, Kay EW, Bantel H, Schulze-Bergkamen H, Prehn JH. Low levels of Caspase-3 predict favourable response to 5FU-based chemotherapy in advanced colorectal cancer: Caspase-3 inhibition as a therapeutic approach. Cell Death Dis. 2016 Feb 4;7:e2087. PMID: 26844701
      • Connolly NM, D’Orsi B, Monsefi N, Huber HJ, Prehn JH. Computational Analysis of AMPK-Mediated Neuroprotection Suggests Acute Excitotoxic Bioenergetics and Glucose Dynamics Are Regulated by a Minimal Set of Critical Reactions. PLoS One. 2016 Feb 3;11(2):e0148326. doi:
        10.1371/journal.pone.0148326. eCollection 2016. PMID: 26840769
      • Zakaria Z, Tivnan A, Flanagan L, Murray DW, Salvucci M, Stringer BW, Day BW, Boyd AW, Kögel D, Rehm M, O’Brien DF, Byrne  AT, Prehn JH. Patient-derived glioblastoma cells show significant heterogeneity in treatment responses to the inhibitor-of-apoptosis-protein antagonist birinapant. Br J Cancer. 2015 Dec 10. doi: 10.1038/bjc.2015.420. [Epub ahead of print]. PMID: 26657652
    • • Nolan K, Walter F, Tuffy LP, Poeschel S,Gallagher R, Haunsberger S, Bray I, Stallings RL, Concannon CG, Prehn JH. ER Stress-Mediated Upregulation of miR-29a Enhances Sensitivity to Neuronal Apoptosis.Eur J Neurosci. 2016 Jan 10.PMID: 26750440

2015:

• • • • Pfeiffer S, Prehn JH.The esoteric roles of Bcl-2 family proteins in glucose homeostasis and cell survival. Cell Death Dis. 2015 Nov PMID: 26539915
      • Bacon S, Engelbrecht B, Schmid J, Pfeiffer S, Gallagher R, McCarthy A, Burke M, Concannon C, Prehn JH, Byrne MM. MicroRNA-224 is Readily Detectable in Urine of Individuals with Diabetes Mellitus and is a Potential Indicator of Beta-Cell Demise. Genes (Basel). 2015 Jun 23;6(2):399-416. PMID: 26110317
      • Flanagan L, Kehoe J, Fay J, Bacon O, Lindner AU, Kay EW, Deasy J, McNamara DA, Prehn JH.High levels of X-linked
        Inhibitor-of-Apoptosis Protein (XIAP) are indicative of radio chemotherapy resistance in rectal cancer. Radiat Oncol. 2015 Jun 13;10(1):131. [Epub ahead of print] PMID: 26071313
      • Dmitriev RI, Borisov SM, Dussman H, Sun S, Muller BJ, Prehn J, Baklaushev VP, Klimant I, Papkovsky DB.Versatile Conjugated Polymer Nanoparticles for High-Resolution O2 Imaging in Cells and 3D Tissue Models. ACS Nano. 2015 Apr 10. [Epub ahead of print], PMID: 25858428
      • Walter F, Schmid J, Düssmann H, Concannon CG, Prehn JH.Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival. Cell Death Differ. 2015 Jan 30 PMID: 25633195
      • D’Orsi B, Kilbride SM, Chen G, Perez Alvarez S,Bonner HP, Pfeiffer S, Plesnila N, Engel T, Henshall DC, Düssmann H, Prehn JH. Bax regulates neuronal Ca2+ homeostasis. J Neurosci. 2015 Jan 28;35(4):1706-22. PMID: 25632145

2014:

• • • • • Coughlan KS, Mitchem MR, Hogg MC, Prehn JH. “Preconditioning” with
          latrepirdine, an adenosine 5′-monophosphate-activated protein kinase activator,
          delays amyotrophic lateral sclerosis progression in SOD1^G93A mice. Neurobiol Aging. 2014 Sep 26. [Epub ahead of print] PMID: 25443289
        • Flanagan L, Lindner AU, de Chaumont C, Kehoe J, Fay J, Bacon O, Toomey S, Huber HJ, Hennessy BT, Kay EW, McNamara DA, Prehn JH. BCL2 protein signalling determines acute responses to neoadjuvant chemoradiotherapy in rectal cancer. JMol Med (Berl). 2014 Nov 13. PMID: 25388617
        • Jarzabek MA, Amberger-Murphy V, Callanan JJ, Gao C, Zagozdzon AM, Shiels L, Wang J, Ligon KL, Rich BE, Dicker P, Gallagher WM, Prehn JH, Byrne AT. Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models. Br J Cancer. 2014 Nov 6. [Epub ahead of print] PMID: 25375271
        • Anilkumar U, Prehn JH. Anti-apoptotic BCL-2 familyproteins in acute neural injury. Front Cell Neurosci. 2014 Sep 30;8:281. Review. PMID: 25324720
        • Pfeiffer S, Anilkumar U, Chen G, Ramírez-Peinado S, Galindo-Moreno J, Muñoz-Pinedo C, Prehn JH. Analysis of BH3-only proteins upregulated in response to oxygen/glucose deprivation in cortical neurons identifies Bmf but not Noxa as potential mediator of neuronal injury. Cell Death Dis. 2014 Oct 9;5:e1456.PMID: 25299781
        • Connolly NM, Prehn JH. The metabolic response to excitotoxicity – lessons from single-cell imaging. J Bioenerg Biomembr. 2014 Sep 28 [Epub ahead of print].
        • Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DiDaniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S,Garrido C, Gougeon ML, Green DR,Gronemeyer H, Hajnoczky G, Hardwick JM,Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW,
          Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G.Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 2014 Sep 19. doi:
          10.1038/cdd.2014.137. [Epub ahead of print] PMID: 25236395
        • Dávila D, Jiménez-Mateos EM, Mooney CM, Velasco G, Henshall DC, Prehn JH. Hsp27 binding to the 3’UTR of bim mRNA prevents neuronal death during oxidative stress-induced injury – a novel cytoprotective mechanism. Mol Biol Cell. 2014 Sep 3. pii: mbc.E13-08-0495. PMID: 25187648
        • Connolly NM, Düssmann H, Anilkumar U, Huber HJ, Prehn JH. Single-Cell Imaging of Bioenergetic Responses to Neuronal Excitotoxicity and Oxygen and Glucose Deprivation. J Neurosci. 2014 Jul 30;34(31):10192-10205. PMID: 25080581
        • Dmitriev RI, Borisov SM, Kondrashina AV, Pakan JM, Anilkumar U, Prehn JH, Zhdanov AV, McDermott KW, Klimant I, Papkovsky DB.Imaging oxygen in neural
          cell and tissue models by means of anionic cell-permeable phosphorescent
          nanoparticles.Cell Mol Life Sci. 2014 Jul 9. [Epub ahead of print] PMID: 25006059
        • König HG, Coughlan KS, Kinsella S, Breen BA, Prehn JH. The BCL-2 family protein Bid is critical for pro-inflammatory signaling in astrocytes. Neurobiol Dis. 2014 Jun 20. pii: S0969-9961(14)00172-7. doi: 10.1016/j.nbd.2014.06.008. [Epub ahead of print]
        • Sweeney KJ, Jarzabek MA, Dicker P, O’Brien DF,Callanan JJ, Byrne AT, Prehn JH. Validation of an Imageable Surgical Resection Animal Model of Glioblastoma (GBM). J Neurosci Methods. 2014 Jun 18. pii: S0165-0270(14)00160-5. doi: 10.1016/j.jneumeth.2014.05.006. [Epub ahead of print]
        • M L Würstle, E Zink, J H M Prehn and M Rehm. From computational modelling of the intrinsic apoptosis pathway to a systems-based analysis of chemotherapy resistance: achievements, perspectives and challenges in systems medicine. Cell Death and Disease (2014) 5, e1258; doi:10.1038/cddis.2014.36 Published online 29 May 2014
        • Abdul-Jalil KI, Sheehan KM, Toomey S, Schmid J, Prehn J, O’Grady A, Cummins R, O’Neill B, McNamara DA, Deasy J, Breathnach O, Grogan L, Rogers A, Doherty G, Winter D, Ryan J, El-Masry S, Gibbons D, Sheahan K, Gillen P, Kay EW, Hennessy BT. The Frequencies and Clinical Implications of Mutations in 33 Kinase-Related Genes in Locally Advanced Rectal Cancer: A Pilot Study. Ann Surg Oncol. 2014 Apr 4. [Epub ahead of print] PMID: 24700299
        • Nolan K, Mitchem MR, Jimenez-Mateos EM, Henshall DC, Concannon CG, Prehn JH.Increased Expression of MicroRNA-29a in ALS Mice: Functional Analysis of Its Inhibition. J Mol Neurosci. 2014 Apr 4 [Epub ahead of print] PMID: 24696165
        • Huber HJ, McKiernan RG, Prehn JH.Harnessing system models of cell death signalling for cytotoxic chemotherapy: towards personalised medicine approaches? J Mol Med (Berl). 2014 Jan 30. [Epub ahead of print] PMID: 24477766
        • Delgado ME, Dyck L, Laussmann MA, Rehm M. Modulation of apoptosis sensitivity through the interplay with autophagic and proteasomal degradation pathways. Cell Death Dis. 2014 Jan 23;5:e1011. doi: 10.1038/cddis.2013.520. PMID: 24457955

2013:

• • • • • Ramapathiran L, Bernas T, Walter F, Williams L, Düssmann H, Concannon CG, Prehn JH. Single cell imaging of the heat shock response during proteasome inhibitor-induced apoptosis in colon cancer cells suggests that magnitude and length rather than time of onset determines resistance to apoptosis.  J Cell Sci. 2013 Nov 27. [Epub ahead of print] PMID: 24284067
        • Murphy AC, Weyhenmeyer B, Noonan J, Kilbride SM, Schimansky S, Loh KP, Kögel D, Letai AG, Prehn JH, Murphy BM. Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis. Apoptosis. 2013 Nov 9. [Epub ahead of print] PMID: 24213561
        • Hogg MC, Prehn JH. Endonuclease-G and the pathways to dopaminergic neurodegeneration: a question of location? EMBO J. 2013 Oct 25. doi: 10.1038/emboj.2013.238 PMID: 24162725
        • Weisová P, Alvarez SP, Kilbride SM, Anilkumar U, Baumann B, Jordán J, Bernas T, Huber HJ, Düssmann H, Prehn JH.; Latrepirdine is a potent activator of AMP-activated protein kinase and reduces neuronal excitability.  Transl Psychiatry. 2013 Oct 22;3:e317. doi: 10.1038/tp.2013.92 PMID: 24150226
        • E Passante, M L Würstle, C T Hellwig, M Leverkus and M Rehm; Systems analysis of apoptosis protein expression allows the case-specific prediction of cell death responsiveness of melanoma cells. Cell Death Differ. 2013 Aug 9. doi: 10.1038/cdd.2013.106. PMID: 23933815
        • Skorupa A, Urbach S, Vigy O, King MA, Chaumont-Dubel S, Prehn JH, Marin P. Angiogenin Induces Modifications in the Astrocyte Secretome: Relevance to Amyotrophic Lateral Sclerosis. J Proteomics. 2013 Aug 3. PMID: 23920243
        • Boland K, Flanagan L, Prehn JH. Paracrine control of tissue regeneration and cell proliferation by Caspase-3. Cell Death Dis. 2013 Jul 11; PMID: 23846227
        • Lindner AU, Prehn JH, Huber HJ. The indirect activation model of mitochondrial outer membrane permeabilisation (MOMP) initiation requires a trade-off between robustness in the absence of and sensitivity in the presence of stress. Mol Biosyst. 2013 Jul 4. PMID: 23824068
        • Kyithar MP, Bonner C, Bacon S, Kilbride SM, Schmid J, Graf R, Prehn JH, Byrne MM. Effects of hepatocyte nuclear factor-1A and -4A on pancreatic stone protein/regenerating protein and C-reactive protein gene expression: Implications for maturity-onset diabetes of the young. J Transl Med. 2013 Jun 26;11(1):156. PMID: 23803251
        • Jarzabek MA, Sweeney KJ, Evans RL, Jacobs AH, Stupp R, O’Brien D, Berger MS, Prehn JH, Byrne AT. Molecular imaging in the development of a novel treatment paradigm for glioblastoma multiforme: An integrated multidisciplinary commentary. Drug Discov Today. 2013 Jun 20. doi:pii: S1359-6446(13)00167-0. 10.1016/j.drudis.2013.06.004. PMID: 23792334
        • Delgado ME, Olsson M, Lincoln FA, Zhivotovsky B, Rehm M. Determining the Contributions of Caspase-2, Caspase-8 and Effector Caspases to Intracellular VDVADase Activities during Apoptosis Initiation and Execution. Biochim Biophys Acta. 2013 Jun 6. PMID: 23747563
        • Murphy AC, Weyhenmeyer B, Schmid J, Kilbride SM, Rehm M, Huber HJ, Senft C, Weissenberger J, Seifert V, Dunst M, Mittelbronn M, Kögel D, Prehn JH, Murphy BM. Activation of executioner caspases is a predictor of progression-free survival in glioblastoma patients: a systems medicine approach. Cell Death Dis. 2013 May 16;4:e629. doi: 10.1038/cddis.2013.157. PMID: 23681224
        • Bonner C, Nyhan KC, Bacon S, Kyithar MP, Schmid J, Concannon CG, Bray IM, Stallings RL, Prehn JH, Byrne MM. Identification of circulating microRNAs in HNF1A-MODY carriers. Diabetologia. 2013 May 15. PMID: 23674172
        • Rehm M, Prehn JH. Systems modelling methodology for the analysis of apoptosis signal transduction and cell death decisions. Methods. 2013 Apr 19. PMID: 23607991
        • Jarzabek MA, Huszthy PC, Skaftnesmo KO, McCormack E, Dicker P, Prehn JH, Bjerkvig R, Byrne AT. In Vivo Bioluminescence Imaging Validation of a Human Biopsy-derived Orthotopic Mouse Model of Glioblastoma Multiforme. Mol Imaging. 2013 Mar 1;12(2):1-12. PMID: 23422278
        • Engel T, Sanz-Rodgriguez A, Jimenez-Mateos EM, Concannon CG, Jimenez-Pacheco A, Moran C, Mesuret G, Petit E, Delanty N, Farrell MA, O’Brien DF, Prehn JH, Lucas JJ, Henshall DC. CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures. Brain. 2013 Jan 29. PMID: 23361066
        • Lindner AU, Concannon CG, Boukes GJ, Cannon MD, Llambi F, Ryan D, Boland K, Kehoe J, McNamara DA, Murray F, Kay EW, Hector S, Green DR, Huber HJ, Prehn JH. Systems Analysis of BCL2 Protein Family Interactions Establishes a Model to Predict Responses to Chemotherapy. Cancer Res. 2013 Jan 15;73(2):519-28. doi: 10.1158/0008-5472.CAN-12-2269. PMID: 23329644

2012:

• • • • • Anilkumar U, Weisová P, Düssmann H, Concannon CG, König HG, Prehn JH. AMP-activated Protein Kinase (AMPK)-Induced Preconditioning in Primary Cortical Neurons Involves Activation of MCL-1. J Neurochem. 2012 Nov 30. doi: 10.1111/jnc.12108. PMID: 23199202
        • Aparicio-Erriu IM, Prehn JH. Molecular Mechanisms in Amyotrophic Lateral Sclerosis: The Role of Angiogenin, a Secreted RNase. Front Neurosci. 2012;6:167. doi: 10.3389/fnins.2012.00167. Epub 2012 Nov 19. PMID: 23181008
        • König HG, Fenner BJ, Byrne JC, Schwamborn RF, Bernas T, Jefferies CA, Prehn JH. Fibroblast growth factor homologous factor 1 interacts with NEMO to regulate NF-κB signaling in neurons. J Cell Sci. 2012 Oct 24. PMID: 23097049
        • Weyhenmeyer B, Murphy AC, Prehn JH, Murphy BM. Targeting the anti-apoptotic bcl-2 family members for the treatment of cancer. Exp Oncol. 2012 Oct;34(3):192-9. PubMed PMID: 23070004.
        • Schmid J, Dussmann H, Boukes GJ, Flanagan L, Lindner AU, O’Connor CL, Rehm M, Prehn JH, Huber HJ. Systems analysis of cancer cell heterogeneity in caspase-dependent apoptosis subsequent to mitochondrial outer membrane permeabilisation. J Biol Chem. 2012 Oct 4. [Epub ahead of print] PMID: 23038270
        • Kilbride SM, Prehn JH. Central roles of apoptotic proteins in mitochondrial function. Oncogene. 2012 Aug 6. doi: 10.1038/onc.2012.348. [Epub ahead of print] PubMed PMID: 22869150.
        • Bacon S, Kyithar MP, Schmid J, Rizvi SR, Bonner C, Graf R, Prehn JH, Byrne MM. Serum levels of pancreatic stone protein (PSP)/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1
          alpha (HNF1A-MODY) carriers from the third decade of life onward.BMC Endocr Disord. 2012 Jul 18;12:13. doi: 10.1186/1472-6823-12-13. PubMed PMID: 22808921; PubMed Central PMCID: PMC3433346.
        • Ionescu CM, Svobodova-Varekova R, Prehn JHM, Huber HJ, Koca J, Charge Profile Analysis Reveals That Activation of Pro-apoptotic Regulators Bax and Bak Relies on Charge Transfer Mediated Allosteric Regulation, Plos Comp. Biol., doi:10.1371/journal.pcbi.1002565
        • Weisová P, Anilkumar U, Ryan C, Concannon CG, Prehn JH, Ward MW. ‘Mild
          mitochondrial uncoupling’ induced protection against neuronal excitotoxicity
          requires AMPK activity. Biochim Biophys Acta. 2012 May;1817(5):744-53. Epub 2012
          Feb 7. PubMed PMID: 22336583.
        • Davila D, Connolly NM, Bonner H, Weisova P, Dussmann H, Concannon C, Huber HJ, Prehn J, Two step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate, Cell Death Diff. 2012 Apr 27. doi: 10.1038/cdd.2012.49. [Epub ahead of print] PMID:22539004
        • Hector S, Conlon S, Schmid J, Dicker P, Cummins RJ, Concannon CG, Johnston PG, Kay EW, Prehn JH. Apoptosome-dependent caspase activation proteins as prognostic markers in Stage II and III colorectal cancer., Br J Cancer. 2012 Apr 24;106(9):1499-1505. doi: 10.1038/bjc.2012.133
        • Skorupa A, King MA, Aparicio IM, Dussmann H, Coughlan K, Breen B, Kieran D,
          Concannon CG, Marin P, Prehn JH. Motoneurons secrete angiogenin to induce RNA
          cleavage in astroglia. J Neurosci. 2012 Apr 11;32(15):5024-38. PubMed PMID:
          22496549.
        • Laussmann MA, Passante E, Hellwig CT, Tomiczek B, Flanagan L, Prehn JH, Huber HJ, Rehm M. Proteasome inhibition can impair caspase-8 Activation upon sub-maximal Stimulation of apoptotic tumour necrosis factor-related apoptosis inducing ligand (TRAIL) signalling. J Biol Chem, 2012 Mar 9; [Epub ahead of print]. PMID 22408249
        • Sehnal D, Svobodova-Varekova R, Huber HJ, Geidl S, Ionescu CM, Wimmerova M, Koca J, SiteBinder – an improved approach for comparing multiple protein structural motifs, J. Chem. Inf. Model. 2012 (PMID 22296449)
        • Huber HJ, Connolly NM, Dussmann H, Prehn JHM,  A structured approach to the study of metabolic control principles in intact and impaired mitochondria, Molecular Biosystems, 2012 Mar;8(3):828-42.
        • D’Orsi B, Bonner H, Tuffy LP, Düssmann H, Woods I, Courtney MJ, Ward MW, Prehn JH. Calpains are downstream effectors of bax-dependent excitotoxic apoptosis. J Neurosci. 2012 Feb 1;32(5):1847-58. PubMed PMID: 22302823.
        • Hector S, Chen H, Kijanka G, Murray F, Prehn JH. A reverse-ELISA for the
          detection of TRIM28/KAP1 serum autoantibodies in colorectal cancer patients. Acta
          Oncol. 2012 Mar;51(3):394-6. Epub 2012 Jan 24. PubMed PMID: 22268577.
        • Lopez-Caamal F, Garcia M, Middleton RH, Huber HJ, Positive Feedback in the AKT/mTOR pathway and its implications for growth signal progression in skeletal muscle cells, J. Theor. Biol. 2012 Feb 2;301C:15-27.
        • Würstle ML, Laussmann MA, Rehm M. The central role of initiator caspase-9 in apoptosis signal transduction and the regulation of its activation and activity on the apoptosome. Exp Cell Res 2012 (Special Issue on Cell Death Signalling) in press. PMID: 22406265
        • Hellwig CT, Rehm M. TRAIL signalling and synergy mechanisms used in TRAIL-based combination therapies. Mol Cancer Ther. 2012 Jan;11(1):3-13. PMID: 22234808.

2011:

• • • • • Hector S, Rehm M, Schmid J, Kehoe J, McCawley N, Dicker P, Murray F, McNamara D, Kay EW, Concannon CG, Huber HJ, Prehn JH. Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy. Gut. 2011 Nov 14. [Epub ahead of print] PMID: 22082587
        • McCawley N, Conlon S, Hector S, Cummins RJ, Dicker P, Johnston PG, Kay EW, McNamara DA, Prehn JH, Concannon CG. Analyzing proteasomal subunit expression reveals Rpt4 as a prognostic marker in stage II colorectal cancer. Int J Cancer. 2011 Sep 29. doi: 10.1002/ijc.26468. PMID: 21960357
          Farrelly AM, Kilbride SM, Bonner C, Prehn JH, Byrne MM. Rapamycin protects against dominant negative-HNF1A-induced apoptosis in INS-1 cells. Apoptosis. 2011 Nov;16(11):1128-37.PMID: 21874357
        • Vader P, van der Meel R, Symons M H, Fens M H A M, Pieters E, Wilschut K J, Storm G, Jarzabek M, Gallagher W, Schiffelers R M, Byrne A T Examining the role of Rac1 in tumor angiogenesis and growth: a clinically relevant RNAi-mediated approach. Angiogenesis. 2011 Dec;14(4):457-66. Epub 2011 Jul 26. PMID: 21789714
        • Kedziora KM, Prehn JH, Dobrucki J, Bernas T. Method of calibration of a fluorescence microscope for quantitative studies. J Microsc. 2011 Oct;244(1):101-11. doi: 10.1111/j.1365-2818.2011.03514.x. Epub 2011 Jul 14. PMID: 21756257
        • Bonner C, Farrelly AM, Concannon CG, Dussmann H, Baquié M, Virard I, Wobser H, Kögel D, Wollheim CB, Rupnik M, Byrne MM, König HG, Prehn JH. Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation.  J Biol Chem. 2011 Jul 22;286(29):25719-28. Epub 2011 May 31. PMID: 21628466
        • Hams E, Saunders SP, Cummins EP, O’Connor A, Tambuwala MT, Gallagher WM, Byrne AT, Campos-Torres A, Moynagh PM, Jobin C, Taylor CT, Fallon PG. The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells. Shock. 2011 Sep;36(3):295-302. PMID: 21844787
        • Huber HJ, Dussmann H, Kilbride SM, Rehm M, Prehn JH. Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release. Mol Syst Biol. 2011 Mar 1;7:470. PMID: 21364572
        • Laussmann MA, Passante E, Dussmann H, Rauen JA, Würstle ML, Delgado ME, Devocelle M, Prehn JH, Rehm M . Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8.Cell Death Differ. PMID: 21455219
        • O’Connor AE, McGee MM, Likar Y, Ponomarev V, Callanan JJ, O’shea DF, Byrne AT, Gallagher WM . Mechanism of cell death mediated by a BF(2) -chelated tetraaryl-azadipyrromethene photodynamic therapeutic: Dissection of the apoptotic pathway in vitro and in vivo. International Journal of Cancer 2011 Mar 16. doi: 10.1002/ijc.26073. PMID: 21413012
        • Engel T, Plesnila N, Prehn JH, Henshall DC. In vivo contributions of BH3-only
          proteins to neuronal death following seizures, ischemia, and traumatic brain
          injury. J Cereb Blood Flow Metab. 2011 May;31(5):1196-210. Epub 2011 Mar 2.
          Review. PubMed PMID: 21364604; PubMed Central PMCID: PMC3099642.
        • Van der Meel R, Symons MH, Kudernatsch R, Kok RJ, Schiffelers RM, Storm G, Gallagher WM, Byrne AT.The VEGF/Rho GTPase signalling pathway: a promising target for anti-angiogenic/anti-invasion therapy. Drug Discov Today, 2011 Mar;16(5-6):219-28. Epub 2011 Jan 22.PMID: 21262381
        • Huber HJ, Dussmann H, Kilbride SM, Rehm M, Prehn JH. AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF. Mol Syst Biol. 2011 Mar 1;7:470. PMID: 21364572
        • Flanagan L, Sebastia J, Delgado ME, Lennon JC, Rehm M. Dimerization of Smac is crucial for its mitochondrial retention by XIAP subsequent to mitochondrial outer membrane permeabilization. Biochim Biophys Acta. 2011 Feb 23. [Epub ahead of print] PMID: 21354220
        • Tummala R, Diegelman P, Hector S, Kramer DL, Clark K, Zagst P, Fetterly G, Porter CW, Pendyala L. Combination effects of platinum drugs and N1, N11 diethylnorspermine on spermidine/spermine N1-acetyltransferase, polyamines and growth inhibition in A2780 human ovarian carcinoma cells and their oxaliplatin and cisplatin-resistant variants. Cancer Chemother Pharmacol. 2011 Feb;67(2):401-14. Epub 2010 May 5. PMID:20443003
        • Tsuchiya T, Bonner HP, Engel T, Woods I, Matsushima S, Ward MW, Taki W,
          Henshall DC, Concannon CG, Prehn JH. Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome
          inhibition in vivo. Eur J Neurosci. 2011 Feb;33(3):401-8. doi: 10.1111/j.1460-9568.2010.07538.x. Epub 2010 Dec 31. PubMed PMID: 21198986.
        • Hellwig CT, Passante E, Rehm M.The molecular machinery regulating apoptosis signal transduction and its implication in human physiology and pathophysiologies. Curr Mol Med. 2011 Feb;11(1):31-47. Review. PMID: 21189119

2010:

• • • • • Ludwig-Galezowska AH, Flanagan L, Rehm M . Apoptosis repressor with caspase recruitment domain, a multifunctional modulator of cell death. J Cell Mol Med. 2010 Dec 3. [Epub ahead of print] PMID: 21129150
        • Bonner C, Bacon S, Concannon CG, Rizvi SR, Baquié M, Farrelly AM, Kilbride SM, Dussmann H, Ward MW, Boulanger CM, Wollheim CB, Graf R, Byrne MM, Prehn JH.INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells. Diabetes. 2010 Nov;59(11):2799-808. Epub 2010 Aug 3. PMID: 20682686
        • Flanagan L, Sebastià J, Tuffy LP, Spring A, Lichawska A, Devocelle M, Prehn JH, Rehm M. XIAP impairs Smac release from the mitochondria during apoptosis. Cell Death Dis. 2010 Jun 3;1(6):e49. PMID: 21364655
        • Huber HJ, Duessmann H, Wenus J, Kilbride SM, Prehn JH Mathematical modelling of the mitochondrial apoptosis pathway. Biochim Biophys Acta. 2011 Apr;1813(4):608-15. Epub 2010 Oct 13.
        • Fitzpatrick SF, Tambuwala MM, Bruning U, Schaible B, Scholz CC, Byrne A, O’Connor A, Gallagher WM, Lenihan CR, Garvey JF, Howell K, Fallon PG, Cummins EP, Taylor CT . An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxia.J Immunol. 2011 Jan 15;186(2):1091-6. PMID: 21149600.
        • Kilbride SM, Farrelly AM, Bonner C, Ward MW, Nyhan KC, Concannon CG, Wollheim CB, Byrne MM, Prehn JH . AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF.J Biol Chem. 2010 Nov 12;285(46):36199-206. Epub 2010 Sep 14.PMID:20841353
        • Concannon CG, Tuffy LP, Weisová P, Bonner HP, Dávila D, Bonner C, Devocelle
          MC, Strasser A, Ward MW, Prehn JH. AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis. J Cell Biol. 2010 Apr 5;189(1):83-94. Epub 2010 Mar 29. PubMed PMID: 20351066; PubMed Central PMCID: PMC2854380.
        • Würstle ML, Laussmann MA, Rehm M . The caspase-8 dimerization/dissociation balance is a highly potent regulator of caspase-8, -3, -6 signaling. J Biol Chem. 2010 Aug 11. PMID: 20702410
        • Hellwig CT, Ludwig-Galezowska AH, Concannon CG, Litchfield DW, Prehn JH, Rehm M. Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation.. J Cell Sci. 2010 May 1;123(Pt 9):1401-6. Epub 2010 Mar 31. PMID: 20356928
        • Strathmann J, Klimo K, Sauer SW, Okun JG, Prehn JH, Gerhäuser C. Xanthohumol-induced transient superoxide anion radical formation triggers cancer cells into apoptosis via a mitochondria-mediated mechanism.. FASEB J. 2010 Aug;24(8):2938-50. Epub 2010 Mar 24. PMID: 20335224
        • Paul P, Duessmann H, Bernas T, Huber H, Kalamatianos D. Automatic noise quantification for confocal fluorescence microscopy images. Comput Med Imaging Graph. 2010 Sep;34(6):426-34. Epub 2010 May 13. PMID: 20462738
        • O’Donovan N, Byrne A, O’Connor AE, McGee S, Gallagher WM, Crown J. Synergistic interaction between trastuzumab and EGFR/HER-2 tyrosine kinase inhibitors in HER-2 positive breast cancer cells. Invest New Drugs. 2011 Oct;29(5):752-9. Epub 2010 Mar 16. PMID: 20229355
        • O’Neill K, Lyons SK, Gallagher WM, Curran KM, Byrne AT Bioluminescent imaging: a critical tool in pre-clinical oncology research. J Pathol 2010 Feb;220(3):317-27 PMID: 19967724
        • Fens MH, Storm G, Pelgrim RC, Ultree A, Byrne AT, Gaillard CA, van Solinge WW, Schiffelers RM . Erythrophagocytosis by angiogenic endothelial cells is enhanced by loss of erythrocyte deformability. Exp Hematol. 2010 Apr;38(4):282-91. Epub 2010 Feb 8. PMID: 20146933
        • Huber HJ, Laussmann MA, Prehn JH, Rehm M. Diffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death. BMC Syst Biol. 2010 Feb 4;4:9. PMID: 20132548
        • Dervan EW, Chen H, Ho SL, Brummel N, Schmid J, Toomey D, Haralambova M, Gould E, Wallace DM, Prehn JH, O’Brien CJ, Murphy D. Protein macroarray profiling of serum autoantibodies in pseudoexfoliation glaucoma.. Invest Ophthalmol Vis Sci. 2010 Jun;51(6):2968-75. Epub 2010 Jan 27. PMID: 20107165
        • Fenner BJ, Scannell M, Prehn JH. Expanding the substantial interactome of NEMO using protein microarrays. PLoS One. 2010 Jan 20;5(1):e8799. PMID: 20098747
        • Kijanka G, Hector S, Kay EW, Murray F, Cummins R, Murphy D, MacCraith BD, Prehn JH, Kenny D. Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer.. Gut. 2010 Jan;59(1):69-78. Epub . PMID: 19828471

2009:

• • • • • Wenus J, Dussmann H, Paul P, Kalamatianos D, Rehm M, Wellstead P, Prehn JH, Huber HJ . ALISSA: an automated live-cell imaging system for signal transduction analyses. Biotechniques. 2009 Dec;47(6):1033-40 PMID: 20041856
        • Byrne AT, O’Connor AE, Hall M, Murtagh J, O’Neill K, Curran KM, Mangrain K, Rousseau JA, Lecomte R, McGee S, Callanan JJ, O’Shea DF, Gallagher WM . Vascular-targeted photodynamic therapy with BF2-chelated Tetraaryl-Azadipyrromethene agents: a multi-modality molecular imaging approach to therapeutic assessment. Br J Cancer. 2009 Nov 3;101(9):1565-73. Epub 2009 Oct 13.    PMID: 19826417
        • Düssmann H, Rehm M, Concannon CG, Anguissola S, Würstle M, Kacmar S, Völler P, Huber HJ, Prehn JH. Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation. Cell Death Differ. 2010 Feb;17(2):278-90. Epub 2009 Sep 11. PMID:19745831
        • O’Connor AE, Gallagher WM, Byrne AT . Porphyrin and nonporphyrin photosensitizers in oncology: preclinical and clinical advances in photodynamic therapy.  Photochem Photobiol. 2009 Sep-Oct;85(5):1053-74. Epub 2009 Aug 3PMID: 19682322
        • Anguissola S, Köhler B, O’Byrne R, DüsSMann H, Cannon MD, Murray FE, Concannon CG, Rehm M, Kögel D, Prehn JH.  Bid and calpains cooperate to trigger oxaliplatin-induced apoptosis of cervical carcinoma HeLa cells. Mol Pharmacol. 2009 Nov;76(5):998-1010. Epub 2009 Aug 27. PMID: 19713356
        • Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ. 2009 Aug;16(8):1093-107. Epub 2009 Apr 17. Review. PMID:19373242
        • Fenner BJ, Scannell M, Prehn JH. Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays. Biochim Biophys Acta. 2009 Jul;1794(7):1010-6. Epub 2009 Mar 11. PMID: 19285159
        • Hector S, Prehn JH. Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer: a review. Biochim Biophys Acta. 2009 Apr;1795(2):117-29. Epub 2009 Jan 6. Review. PMID:19167459
        • Rehm M, Huber HJ, Hellwig CT, Anguissola S, Dussmann H, Prehn JH. Dynamics of outer mitochondrial membrane permeabilization during apoptosis.  Cell Death Differ. 2009 Apr;16(4):613-23. Epub 2009 Jan 9. PMID: 19136937
        • Farrelly AM, Wobser H, Bonner C, Anguissola S, Rehm M, Concannon CG, Prehn JH, Byrne MM. Early loss of mammalian target of rapamycin complex 1 (mTORC1) signalling and reduction in cell size during dominant-negative suppression of hepatic nuclear factor 1-alpha (HNF1A) function in INS-1 insulinoma cells. Diabetologia. 2009 Jan;52(1):136-44. Epub 2008 Oct 24. PMID: 18949455
        • Huber HJ, Plchut M, Weisová P, Düssmann H, Wenus J, Rehm M, Ward MW, Prehn JH. TOXI-SIM-A simulation tool for the analysis of mitochondrial and plasma membrane potentials.. J Neurosci Methods. 2009 Jan 30;176(2):270-5. Epub 2008 Sep 7. PMID: 18824028

2008:

• • • • • Rudy A, López-Antón N, Barth N, Pettit GR, Dirsch VM, Schulze-Osthoff K, Rehm M, Prehn JH, Vogler M, Fulda S, Vollmar AM. Role of Smac in cephalostatin-induced cell death. Cell Death Differ. 2008 Dec;15(12):1930-40. Epub 2008 Sep 19. PMID: 18806754
        • Hetschko H, Voss V, Senft C, Seifert V, Prehn JH, Kögel D. BH3 mimetics reactivate autophagic cell death in anoxia-resistant malignant glioma cells. Neoplasia. 2008 Aug;10(8):873-85. PMID:18670645
        • O’Connor CL, Anguissola S, Huber HJ, Dussmann H, Prehn JH, Rehm M. Intracellular signaling dynamics during apoptosis execution in the presence or absence of X-linked-inhibitor-of-apoptosis-protein. Biochim Biophys Acta. 2008 Oct;1783(10):1903-13. Epub 2008 Jun 11. PMID:18590777
        • Hector S, Tummala R,KisielND, Diegelman P, Vijcic S, Clark K, Fakih M, Kramer DL, Porter CW, Pendyala L. Polyamine catabolism in colorectal cancer cells following treatment with oxaliplatin, 5-fluorouracil and N1, N11 diethylnorspermine. Cancer Chemotherapy Pharmacology 2008 Aug;62(3):517-27. Epub 2007 Nov 7., PMID: 17987291.
        • Köhler B, Anguissola S, Concannon CG, Rehm M, Kögel D, Prehn JH. Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands’ apoptotic and synergistic effects.. PLoS One. 2008 Jul 30;3(7):e2844. PMID: 18665234
        • Hellwig CT, Kohler BF, Lehtivarjo AK, Dussmann H, Courtney MJ, Prehn JH, Rehm M. Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation.J Biol Chem. 2008 Aug 1;283(31):21676-85. Epub 2008 Jun 3. PMID: 18522940
        • Hetschko H, Voss V, Seifert V, Prehn JH, Kögel D. Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis. FEBS J. 2008 Apr;275(8):1925-36. Epub 2008 Mar 13. PMID: 18341587
        • Zuse A, Prinz H, Müller K, Schmidt P, Günther EG, Schweizer F, Prehn JH, Los M. 9-Benzylidene-naphtho[2,3-b]thiophen-4-ones and benzylidene-9(10H)-anthracenones as novel tubulin interacting agents with high apoptosis-inducing activity.Eur J Pharmacol. 2007 Dec 1;575(1-3):34-45. Epub 2007 Aug 1. PMID: 17707367

2007:

• • • • • Huber HJ, Rehm M, Plchut M, Düssmann H, Prehn JH. APOPTO-CELL–a simulation tool and interactive database for analyzing cellular susceptibility to apoptosis. Bioinformatics. 2007 Mar 1;23(5):648-50. Epub 2007 Jan 19. PMID:17237051
        • Concannon CG, Koehler BF, Reimertz C, Murphy BM, Bonner C, Thurow N, Ward MW, Villunger A, Strasser A, Kögel D, Prehn JH. Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway. Oncogene. 2007 Mar 15;26(12):1681-92. Epub 2006 Sep 18. PMID:16983338

2006:

• • • • • Rehm M, Huber HJ, Dussmann H, Prehn JH. Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein. EMBO J. 2006 Sep 20;25(18):4338-49. Epub 2006 Aug 24. PMID: 16932741
        • Wobser H, Bonner C, Nolan JJ, Byrne MM, Prehn JH. Downregulation of protein kinase B/Akt-1 mediates INS-1 insulinoma cell apoptosis induced by dominant-negative suppression of hepatocyte nuclear factor-1alpha function. Diabetologia. 2006 Mar;49(3):519-26. Epub 2006 Jan 27. PMID:16440211

2005:

• • • • • McDonnell SO, Hall MJ, Allen LT, Byrne A, Gallagher WM, O’Shea DF. Supramolecular photonic therapeutic agents. J Am Chem Soc. 2005 Nov 30;127(47):16360-1  PMID: 16305199.

2003:

• • • • • Byrne AT, Ross L, Holash J, Nakanishi M, Hu L, Hofmann JI, Yancopoulos GD, . Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model. Clin Cancer Res. 2003 Nov 15;9(15):5721-8. PMID: 14654557
        • Rehm M, Düssmann H, Prehn JH. Real-time single cell analysis of Smac/DIABLO release during apoptosis. J Cell Biol. 2003 Sep 15;162(6):1031-43. PMID:12975347
        • Düssmann H, Kögel D, Rehm M, Prehn JH. Mitochondrial membrane permeabilization and superoxide production during apoptosis. A single-cell analysis. J Biol Chem. 2003 Apr 11;278(15):12645-9. Epub 2003 Jan 30. PMID: 12560329
        • Düssmann H, Rehm M, Kögel D, Prehn JH. Outer mitochondrial membrane permeabilization during apoptosis triggers caspase-independent mitochondrial and caspase-dependent plasma membrane potential depolarization: a single-cell analysis. J Cell Sci. 2003 Feb 1;116(Pt 3):525-36. PMID: 12508113
        • Kögel D, Reimertz C, Düssmann H, Mech P, Scheidtmann KH, Prehn JH. The death associated protein (DAP) kinase homologue Dlk/ZIP kinase induces p19ARF- and p53-independent apoptosis. Eur J Cancer. 2003 Jan;39(2):249-56. Erratum in: Eur J Cancer. 2003 Jul;39(10):1466-8. PMID: 12509958
        • Byrne AT, Southgate J, Brison DR, Leese HJ .Effects of insulin-like growth factors I and II on tumour-necrosis-factor-alpha-induced apoptosis in early murine embryos  Reprod Fertil Dev. 2002;14(1-2):79-83  PMID: 12051527 (Dec 2002)

2002 and Earlier:

• • • Byrne AT,SouthgateJ,Brison DR, Leese HJ. Regulation of apoptosis in the bovine blastocyst by insulin and the insulin-like growth factor (IGF) superfamily. Mol Reprod Dev. 2002 Aug;62(4):489-95.     PMID: 12112582      (Aug 2002)
    • Rehm M, Dussmann H, Janicke RU, Tavare JM, Kogel D, Prehn JH. Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3. J Biol Chem. 2002 Jul 5;277(27):24506-14. Epub 2002 Apr 18. PMID: 11964393
    • Wobser H, Düssmann H, Kögel D, Wang H, Reimertz C, Wollheim CB, Byrne MM, Prehn JH. Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death. J Biol Chem. 2002 Feb 22;277(8):6413-21. Epub 2001 Nov 27. PMID:11724785