Professor Murphy joined the Department of Physiology in 2005. She received her B.Sc. (First Class Honours) in Biotechnology from NUI, Galway in 2000. She then studied in Trinity College Dublin under the supervision of Prof. Seamus Martin and received her Ph.D. in 2004. Her thesis research examined apoptosis-associated caspase activation events. Dr. Murphy continued as a Post Doctoral Research Fellow in the same laboratory before moving to the RCSI. In 2005 she was awarded a Post Doctoral Research Fellowship from the Health Research Board to study the regulation of apoptotic pathways in the epileptic brain. This research was conducted between laboratories in the RCSI and the Dow Neurobiology Lab, Legacy Research Centre, Portland, Oregon, USA. Aside from her research Dr. Murphy was also the Research Programme Co-ordinator for the Summer Programme in Undergraduate Research (a Science Foundation Ireland UREKA site at the RCSI) in 2006/2007.
Professor Murphy is heavily involved in teaching in RCSI and has won a the presidents award for Teaching in 2019.
Dr Murphy’s current research focus is on the activation of apoptosis within gliomas. Her research is funded by grants from the RCSI, HRB. Dr. Murphy has recently been selected as a member of the Irish Association for Cancer Research Council. Dr Murphy will represent RCSI on this council.
Publications: see also https://www.systemsmedicineireland.ie/publications/
Frank A. Lincoln, Dirke Imig, Chiara Boccellato, Viktorija Juric, Janis Noonan, Roland E. Kontermann, Frank Allgower, Brona M. Murphy and Markus Rehm (2018). Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism. Cell Death & Disease Nov 1;9(11):1112. doi: 10.1038/s41419-018-1160-2. [[Epub ahead of print]. PMID: 30385739
Noel J. Aherne, Brona M. Murphy (2018). Radiation-induced Gliomas. Critical Reviews in Oncogenesis 23(1-2):113-118. PMID:
We presented our work, including poster and oral presentations at the following conferences:
- Feb 2018, European Association for Cancer Research: A Matter of Life or Death: From Basic Cell Death Mechanisms to Novel Cancer Treatments, Amsterdam, Netherlands.
- June 2018, Young Cancer Researchers Networking (YCRN), Translational Cancer Research Conference, University College Cork
- Nov 2018, EORTC-NCI-AACR, Convention Centre, Dublin
- Dec 2018, NCRC Annual Symposium, NCRC, Dublin
Dr Marie Claire Fitzgerald
Niamh Scully: PhD student
Katja Rybakova: Research Assistant