Systems simulations for the personalization and optimization of Anti-Cancer Treatments
Markus Rehm and his team published the study in the Journal “Cell Death and Differentiation” (Cell Death Differ. 2013 Nov;20(11):1521-1531). In this study, they were successful in predicting the best treatment option for individual melanoma cell lines by using the novel systems modelling approach SYS-ACT. The elimination of cancer cells by a process called Apoptosis is a mainstay of anti-cancer chemotherapies. Markus Rehm and his team used quantitative data of proteins that regulate this cell death mechanism together with information on their interactions and regulatory functions to predict the treatment outcome for individual cell lines to different apoptosis-inducing drugs. Using these information they were able to select the best treatment option in up to 91% of the cases. Additionally, the investigators could identify optimal co-treatment strategies to overcome resistance in melanoma cells. Their novel approach may contribute to the development of personalized cancer treatments in the future.
The systems model was co-developed and implemented by Dr Maximilian Würstle, a postdoctoral researcher in the group of Dr Rehm. A poster designed by Dr Würstle won the “best poster” price at the European Cell Death Organisation annual conference in Paris in late September 2013. Oral presentations of the study results were given in guest seminars and conference talks in recent months (Dermatology Clinics, University of Dresden; Mount Sinai School of Medicine, New York; 3U Cancer Conference, Dublin; CSHL Cell Death meeting, Cold Spring Harbor).