2021

An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution.Lindner AU, Salvucci M, McDonough E, Cho S, Stachtea X, O’Connell EP, Corwin AD, Santamaria-Pang A, Carberry S, Fichtner M, Van Schaeybroeck S, Laurent-Puig P, Burke JP, McNamara DA, Lawler M, Sood A, Graf JF, Rehm M, Dunne PD, Longley DB, Ginty F, Prehn JHM.Cell Death Differ. 2021 Nov 9. doi: 10.1038/s41418-021-00895-9. Online ahead of print.PMID: 34754079

Stratification of chemotherapy-treated stage III colorectal cancer patients using multiplexed imaging and single-cell analysis of T-cell populations.Stachtea X, Loughrey MB, Salvucci M, Lindner AU, Cho S, McDonough E, Sood A, Graf J, Santamaria-Pang A, Corwin A, Laurent-Puig P, Dasgupta S, Shia J, Owens JR, Abate S, Van Schaeybroeck S, Lawler M, Prehn JHM, Ginty F, Longley DB.Mod Pathol. 2021 Nov 3. doi: 10.1038/s41379-021-00953-0. Online ahead of print.PMID: 34732839

TRAIL signaling promotes entosis in colorectal cancer.Bozkurt E, Düssmann H, Salvucci M, Cavanagh BL, Van Schaeybroeck S, Longley DB, Martin SJ, Prehn JHM.J Cell Biol. 2021 Nov 1;220(11):e202010030. doi: 10.1083/jcb.202010030. Epub 2021 Sep 21.PMID: 34546352

Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer.Lafferty A, O’Farrell AC, Migliardi G, Khemka N, Lindner AU, Sassi F, Zanella ER, Salvucci M, Vanderheyden E, Modave E, Boeckx B, Halang L, Betge J, Ebert MPA, Dicker P, Argilés G, Tabernero J, Dienstmann R, Medico E, Lambrechts D, Bertotti A, Isella C, Trusolino L, Prehn JHM, Byrne AT.Clin Cancer Res. 2021 Nov 1;27(21):5979-5992. doi: 10.1158/1078-0432.CCR-21-0818. Epub 2021 Aug 23.PMID: 34426441

Mucinous Colorectal Cancer is Associated With Expression of the TIM-3 Immune Checkpoint Independently of Microsatellite Instability (MSI) Status.O’Connell E, Salvucci M, Reynolds IS, McNamara DA, Burke JP, Prehn JHM.Ann Surg Oncol. 2021 Nov;28(12):7999-8006. doi: 10.1245/s10434-021-09873-4. Epub 2021 Apr 19.PMID: 33876348

AMPK-regulated miRNA-210-3p is activated during ischaemic neuronal injury and modulates PI3K-p70S6K signalling.Pfeiffer S, Tomašcová A, Mamrak U, Haunsberger SJ, Connolly NMC, Resler A, Düssmann H, Weisová P, Jirström E, D’Orsi B, Chen G, Cremona M, Hennessy BT, Plesnila N, Prehn JHM.J Neurochem. 2021 Nov;159(4):710-728. doi: 10.1111/jnc.15347. Epub 2021 Mar 18.PMID: 33694332


Mitochondrial Carrier Homolog 2 Functionally Co-operates With BH3 Interacting-Domain Death Agonist in Promoting Ca2+-Induced Neuronal Injury.
D’Orsi B, Niewidok N, Düssmann H, Prehn JHM.Front Cell Dev Biol. 2021 Oct 11;9:750100. doi: 10.3389/fcell.2021.750100. eCollection 2021.PMID: 34708044 Free PMC article.

FLINO-A new method for immunofluorescence bioimage normalization.Graf J, Cho S, McDonough E, Corwin A, Sood A, Lindner A, Salvucci M, Stachtea X, Van Schaeybroeck S, Dunne PD, Laurent-Puig P, Longley D, Prehn JHM, Ginty F.Bioinformatics. 2021 Oct 2;38(2):520-6. doi: 10.1093/bioinformatics/btab686. Online ahead of print.PMID: 34601553 Free PMC article.

tRNA-derived fragments: A new class of non-coding RNA with key roles in nervous system function and dysfunction.Fagan SG, Helm M, Prehn JHM.Prog Neurobiol. 2021 Oct;205:102118. doi: 10.1016/j.pneurobio.2021.102118. Epub 2021 Jul 7.PMID: 34245849 Review.

Patients with mesenchymal tumours and high Fusobacteriales prevalence have worse prognosis in colorectal cancer (CRC).Salvucci M, Crawford N, Stott K, Bullman S, Longley DB, Prehn JHM.Gut. 2021 Sep 8:gutjnl-2021-325193. doi: 10.1136/gutjnl-2021-325193. Online ahead of print.PMID: 34497144 Free article.

BCL(X)L and BCL2 increase mitochondrial dynamics in breast cancer cell: Evidence from functional and genetic studies.Lucantoni F, Salvucci M, Dussmann H, Prehn JHM.Biochim Biophys Acta Mol Cell Res. 2021 Sep;1868(10):119095. doi: 10.1016/j.bbamcr.2021.119095. Epub 2021 Jun 30.PMID: 34214511

Development of a protein signature to enable clinical positioning of IAP inhibitors in colorectal cancer.McCann C, Matveeva A, McAllister K, Van Schaeybroeck S, Sessler T, Fichtner M, Carberry S, Rehm M, Prehn JHM, Longley DB.FEBS J. 2021 Sep;288(18):5374-5388. doi: 10.1111/febs.15801. Epub 2021 Mar 27.PMID: 33660894

Mucinous and non-mucinous colorectal cancers show differential expression of chemotherapy metabolism and resistance genes.O’Connell E, Reynolds IS, Salvucci M, McNamara DA, Burke JP, Prehn JHM.Pharmacogenomics J. 2021 Aug;21(4):510-519. doi: 10.1038/s41397-021-00229-5. Epub 2021 Mar 17.PMID: 33731881

tsRNAsearch: A pipeline for the identification of tRNA and ncRNA fragments from small RNA-sequencing data.Donovan PD, McHale NM, Venø MT, Prehn JHM.Bioinformatics. 2021 Jul 13:btab515. doi: 10.1093/bioinformatics/btab515. Online ahead of print.PMID: 34255836

Systemic delivery of antagomirs during blood-brain barrier disruption is disease-modifying in experimental epilepsy.Reschke CR, Silva LFA, Vangoor VR, Rosso M, David B, Cavanagh BL, Connolly NMC, Brennan GP, Sanz-Rodriguez A, Mooney C, Batool A, Greene C, Brennan M, Conroy RM, Rüber T, Prehn JHM, Campbell M, Pasterkamp RJ, Henshall DC.Mol Ther. 2021 Jun 2;29(6):2041-2052. doi: 10.1016/j.ymthe.2021.02.021. Epub 2021 Feb 18.PMID: 33609732 Free article.

An Insight Into the Driver Mutations and Molecular Mechanisms Underlying Mucinous Adenocarcinoma of the Rectum.Reynolds IS, O’Connell E, Fichtner M, Blümel A, Mason SE, Kinross J, McNamara DA, Kay EW, O’Connor DP, Das S, Burke JP, Prehn JHM.Dis Colon Rectum. 2021 Jun 1;64(6):677-688. doi: 10.1097/DCR.0000000000001825.PMID: 33955407

Transcriptional CDK Inhibitors CYC065 and THZ1 Induce Apoptosis in Glioma Stem Cells Derived from Recurrent GBM.Juric V, Düssmann H, Lamfers MLM, Prehn JHM, Rehm M, Murphy BM.Cells. 2021 May 12;10(5):1182. doi: 10.3390/cells10051182.PMID: 34066147 Free PMC article.

BCL(X)L and BCL2 increase the metabolic fitness of breast cancer cells: a single-cell imaging study.Lucantoni F, Salvucci M, Düssmann H, Lindner AU, Lambrechts D, Prehn JHM.Cell Death Differ. 2021 May;28(5):1512-1531. doi: 10.1038/s41418-020-00683-x. Epub 2020 Dec 16.PMID: 33328572

The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL.Di Grande A, Peirs S, Donovan PD, Van Trimpont M, Morscio J, Lintermans B, Reunes L, Vandamme N, Goossens S, Nguyen HA, Lavie A, Lock RB, Prehn JHM, Van Vlierberghe P, Ní Chonghaile T.Blood Adv. 2021 Apr 13;5(7):1963-1976. doi: 10.1182/bloodadvances.2021004177.PMID: 33830207 Free PMC article.

Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling.Naia L, Pinho CM, Dentoni G, Liu J, Leal NS, Ferreira DMS, Schreiner B, Filadi R, Fão L, Connolly NMC, Forsell P, Nordvall G, Shimozawa M, Greotti E, Basso E, Theurey P, Gioran A, Joselin A, Arsenian-Henriksson M, Nilsson P, Rego AC, Ruas JL, Park D, Bano D, Pizzo P, Prehn JHM, Ankarcrona M.BMC Biol. 2021 Mar 24;19(1):57. doi: 10.1186/s12915-021-00979-5.PMID: 33761951 Free PMC article.

Resistance to Cell Death in Mucinous Colorectal Cancer-A Review.O’Connell E, Reynolds IS, McNamara DA, Burke JP, Prehn JHM.Cancers (Basel). 2021 Mar 19;13(6):1389. doi: 10.3390/cancers13061389.PMID: 33808549 Free PMC article. Review.

Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer.Dowling CM, Hollinshead KER, Di Grande A, Pritchard J, Zhang H, Dillon ET, Haley K, Papadopoulos E, Mehta AK, Bleach R, Lindner AU, Mooney B, Düssmann H, O’Connor D, Prehn JHM, Wynne K, Hemann M, Bradner JE, Kimmelman AC, Guerriero JL, Cagney G, Wong KK, Letai AG, Chonghaile TN.Sci Adv. 2021 Jan 15;7(3):eabc4897. doi: 10.1126/sciadv.abc4897. Print 2021 Jan.PMID: 33523897 Free PMC article.