Project Title: Systems Analysis of novel small non-coding RNA in neuronal stress responses: towards novel biomarkers and therapeutics for neurodegenerative disorders-
Project Aim(s):The aim of RNA-NEURO is to reveal the role of small non-coding RNAs in Parkinson’s disease, amyotrophic lateral sclerosis, and frontotemporal dementia, with a view to creating novel therapeutic strategies to treat these disorders.
- Principal Investigator(s)/Researcher(s): Prof Jochen Prehn, Prof Jørgen Kjems, Aarhus, Prof Ruth Slack, Brain & Mind Research, Dr Michael van Es, Dr Giovanni Nardo,, Prof Mark Helm, Dr Marion Hogg, Dr Paul Donovan, Dr Yan Yan, Ms Elisabeth Jirstrom ( PhD student)
- Dementia (including AD and other Dementias)
- Motor Neurone Disease
- Neurodegenerative Disease
- Frontotemporal Dementia (FTD)
Principal Investigator: Prof Jochen Prehn, Royal College of Surgeons In Ireland
- Prof Jochen Prehn, Prof Jørgen Kjems, Aarhus, Prof Ruth Slack, Brain & Mind Research, Dr Michael van Es, Dr Giovanni Nardo,, Prof Mark Helm,
Early Career Investigators:
- Dr Marion Hogg,
- Dr Paul Donovan, Dr Yan Yan, Ms Elisabeth Jirstrom ( PhD student)
Other collaborating Institutes: University/Interdiscipl. Nanoscience Ctr., Aarhus, Denmark, Brain & Mind Research Institute, Ottawa, Canada, Department of Neurology & Neurosurgery, Utrecht, Netherlands, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, Institute of Pharmacy and Biochemistry, Mainz, Germany
Project Website (if applicable): https://rna-neuro.com/
FutureNeuro brings together internationally recognised neuroscientists, clinical neurologists, geneticists, cell-biologists, analytical and materials chemists from five different third level institutions (RCSI, TCD, UCD, DCU, NUI Galway) as well as a wider network of clinical neurologists and other collaborators based around the country.
Work Package 7 on the FN grant
Project Title: Analysis of tiRNA and tiRNA-protein complexes and development of tiRNAs as therapeutics and biomarkers in ALS and epilepsy
Aim: To perform a systematic analysis of tiRNA – protein complexes in ALS and Epilepsy models as well as samples from patients. Binding of tiRNA to protein complexes protect tiRNA from degradation and impacts on their stability, detection ability and function. tiRNA may represent novel regulators of protein translation and miRNA function and represent novel therapeutic targets for neurological disorders. The natural spectrum of tiRNA accumulating in ALS and epilepsy is unknown. Using the pre-clinical mouse models of ALS (SOD1 mt, Fus nt, and TDP-43 mt mice) and epilepsy, we will assess tiRNAs and the composition of tiRNA complexes in these animal models. The researcher will profile tiRNA fragments to establish the profile and compostion of tiRNAs.
- Principal Investigator(s)/Researcher(s): Prof Jochen Prehn
- Early Career Invstigator: Dr Marion Hogg
- Motor Neurone Disease
- Project Website (if applicable): https://www.futureneurocentre.ie/
Collaborative Project Between RNA NEURO (JPND) Grant and Researchers in Gladstone Institute, UCSF
Project Title: Control of neuronal proteostasis by stress-induced transfer RNA fragments (‘tiRNA’) as a common stress pathway across neurodegenerative disorders
- Identify tiRNA/sncRNA fingerprints in AD, ALS, FTD and PD human disease i-neurons
- Determine if tiRNAs affect the survival of i-neurons from controls and ALS, PD and FTD models.
- Principal Investigator(s)/Researcher(s): Prof Jochen Prehn, Royal College of Surgeons in Ireland and Steven Finkbeiner, MD, PhD ( Gladstone Institute, UCSF)
- Neurodegenerative Diseases- (ALS, FTD and PD)
- Institution: RCSI, Gladstone Institute