Glioblastoma Multiforme

Research in to the induction of apoptotic cell death in glioblastoma multiforme (GBM), the most common and aggressive form of brain cancer is another focus of the CSM. Glioblastoma cells are highly resistant to this particular form of cell death, resulting in cancer progression. In particular, the centre is interested in the role played by the Bcl-2 & IAP families in the cell death-resistant phenotype of GBM. The overall aim of the research is to increase the susceptibility of glioblastomas to apoptosis, thereby enabling current therapies to be more effective and hence improve patient survival.