Title of Project:
4D-PD-Omics: Spatiotemporal transcriptome and proteome analysis of α-Synuclein pathology in Parkinson’s disease: Identification of cell type-specific vulnerability and tolerance mechanisms. α-Synuclein (α-Syn) pathology is inextricably linked to the pathogenesis of Parkinson’s disease (PD), yet we have very limited understanding why specific neuronal populations are vulnerable to α-Syn-related PD pathology while others are much more resistant. Likewise, we have very limited knowledge of whether neurons may transition from a resistant state to a vulnerable state, how neuronal vulnerability manifests itself during disease development, how it defines distinct stages of α-Syn pathology, and how other non-neuronal cells (astroglia, microglia, infiltrating immune cells) contribute to these processes. 4DPD-Omics is a consortium of experts in α-Syn biochemistry, neuroanatomy and neuropathology, translational α-Syn disease models, spatial and single cell omics profiling, bioinformatics and systems biology who are ideally positioned to perform an unprecedented, integrated, spatiotemporal transcriptome and proteome analysis of neuronal and non-neuronal responses to α-Syn pathology. More info can be found here
Principal Investigator/ Researcher Names
Professor Jochen Prehn
Prof Donato Di Monte
Dr Ronald Melki
Prof Wilma van de Berg
Prof Mauno Vihinen
Dr Niamh Connolly
Dr György Vámosi
Prof Zbyněk Zdráhal
Masja van het Hoofd