Immunochemical FOBT colorectal cancer screening

A study led by Dr David Hughes (Centre for Systems Medicine, RCSI) examined the relevance of using a two sample quantitative immunochemical faecal occult blood test (FIT) at a high cut off stringency by the first population–based colorectal cancer (CRC) pilot screening programme in Ireland. The manuscript is online from June 10th 2013 in the journal Colorectal Disease*. The CRC miss rate estimated for a single test (23.5%) was unacceptably high when the goal was to maximize the discovery of advanced lesions in the initial screening round. The authors concluded that the two test protocol at a high cut off threshold is suitable to optimize FIT screening in Ireland.

  • *Kelley L, Swan N, Hughes DJ. An analysis of the duplicate testing strategy of an Irish immunochemical FOBT colorectal cancer screening programme. Colorectal Dis. 2013 Jun 10. doi: 10.1111/codi.12310. Epub ahead of print. PMID: 23746062
  • Seminar in Systems Biology of Cell Death and Inflammation

    Prof. Inna Lavrik

    Department for Translational Inflammation Research, Univ. Magdeburg

    Dynamics of CD95/Fas signaling networks

    The Centre for Systems Medicine is pleased to announce another speaker of our seminar series, Prof. Inna Lavrik.

    Prof. Lavrik’s team at the University of Magdeburg investigate apoptosis and inflammation signalling by a combination of experimentation and mathematical modelling and examine how defects in apoptosis/inflammation signalling manifest in human disease.
    Please see the website of the Department for Translational Inflammation Research at University of Magdeburg for more details about her research.

    The talk will be held in Tutorial Room 5, RCSI at 4.00pm 11th July 2013.