A study led by Dr David Hughes (Centre for Systems Medicine, RCSI) examined the relevance of using a two sample quantitative immunochemical faecal occult blood test (FIT) at a high cut off stringency by the first population–based colorectal cancer (CRC) pilot screening programme in Ireland. The manuscript is online from June 10th 2013 in the journal Colorectal Disease*. The CRC miss rate estimated for a single test (23.5%) was unacceptably high when the goal was to maximize the discovery of advanced lesions in the initial screening round. The authors concluded that the two test protocol at a high cut off threshold is suitable to optimize FIT screening in Ireland.
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