Breast-Predict hold second sucessful scientific advisory board meeting

The BREAST-PREDICT team met with members of their Scientific Advisory Board (SAB) on the 11th of September 2015 in UCD. Approximately 45 researchers met with four out of seven members of the Scientific Advisory Board to discuss key developments from year two of the centre’s research programme and to gain advice on future plans. The Scientific Advisory Board members in attendance were Prof. Robert Clarke, Georgetown University, U.S.A.; Dr. Jason Carroll, Cambridge Research Institute, U.K; Prof. Richard Kennedy, Queen’s University Belfast, U.K; and Prof. Liam Murray, also from Queen’s University Belfast.

Ten researchers presented updates on the five different workpackages, sixteen early-stage researchers displayed posters and five researchers presented oral posters to the group. This was followed by an informative discussion session in which members of the Scientific Advisory Board provided feedback to the BREAST-PREDICT team. Overall this was a very enjoyable and productive meeting and we look forward to future discussions and feedback at the end of year three.

Irish Assocaition of Pharmacologists

Congratulations to Dr Alice O’Farrell , Postdoctoral Researcher, Dept of Physiology and Medical Physics & Centre for Systems Medicine (PI Dr Annette Byrne) who won Joint First Prize for best oral presentation at the Annual Irish Association of Pharmacologists conference held at University College Cork on Oct 16th for her presentation entitled “Cardiac Metabolic Pathway Remodelling in Response to Sunitinib Malate”.

Congratulations to Meshal Alanezi

Congratulations to Meshal Alanezi (3rd Year Direct Entry Medicine student) who has been awarded the 2015 RCSI Faculty of Radiologists Fielding Medal for the best medical undergraduate radiology project in a medical school on the island of Ireland . Meshal’s project was completed as part of his “Student Selected Component (SSC)” research placement in the RCSI Laboratory of Tumour Biology & Molecular Imaging (PI Dr Annette Byrne, Graduate Entry Medicine & Department of Physiology & Medical Physics, RCSI Centre for Systems Medicine). The winning project was entitled “Pre-clinical interrogation of Regorafenib response in colorectal cancer using a multi-modality molecular imaging approach” and was supported by Science Foundation Ireland funding received by Dr Byrne in the context of the ‘Colofortell’ Career Development Award (

CSM hosts a guest scientist from Brazil May 2015, the Department of Physiology and Medical Physics and CSM was pleased to host a guest scientist from the Instituto de Bioquímica Médica from the Universidade Federal do Rio de Janeiro in Brazil. Supported by RCSI through SFI/ISCA funding Prof. Gralle worked with Dr. Koenig in conjunction with Dr. Duessman and Prof. Prehn on the implementation of models for localised application of toxins relevant in Alzheimer’s disease and analysed their impact on sub cellular structures (05/05/2015-17/05/2015).

Congratulations to Dr Alice O’Farrell

Congratulations to Dr Alice O’Farrell (Physiology & Medical Physics & Centre for Systems Medicine) who was awarded the 2015 Royal Academy of Medicine in Ireland (RAMI) Barcroft Medal at the Annual Meeting of the Biomedical Sciences Section, which was held at RCSI on June 18th. The Award was made for Alice’s presentation entitled “Cardiac Metabolic Pathway Remodelling in Response to Sunitinib Malate: Potential Role for Positron Emission Tomography in the Cardio-Oncology Setting”.

Congratulations to Dr. Amanda Tivinan

Congratulations to Dr. Amanda Tivinan who has been made Patron of the West Wicklow Cancer Support Group, in addition to setting up the IBTRI (Irish Brain Tumour Research Initiative) a platform for BT researchers throughout Ireland to liaise and collaborate, with future fund raising potential to benefit research here in RCSI.

Her recent publication was published in the Frontiers in Neuroscience journal

The Centre for Systems Medicine welcomes: Dr. Michael Courtney Turku Centre for Biotechnology, Finland.

Lecture entitled “NOS1AP, an adaptor protein linked to neurological diseases, reveals a novel signalling paradigm”

Venue: Albert L.T. 4pm 11th June 2015

Michael Courtney leads a research group focused on neuronal signaling mechanisms and is currently based at the Turku Centre for Biotechnology, Turku, Finland.

Research: After early investigations of the roles of
JNK signalling in neuronal death and development his group focused on
identifying targetable mechanisms by which NMDA receptor signaling influences
neuronal cell fate via activation of the p38MAPK pathway. One of the major NMDA
receptor pathways regulating p38MAPK involves the ternary complex of NMDA
receptor, PSD95 and nNOS. The lab demonstrated that PSD95/nNOS-dependent
pathways could be inhibited by nNOS-derived peptides, resulting in
neuroprotection. They showed that NMDA receptor activity leads to recruitment
of NOS1AP to nNOS and demonstrated that NOS1AP is required for NMDA-evoked
stress-activated MAPK responses and downstream excitotoxic consequences. They
developed a selective inhibitor peptide of the interaction between NOS1AP and
nNOS, with neuroprotective properties in cell cultures and in vivo (in a
preclinical model of perinatal asphyxia). More recently they identified that
interaction of nNOS with NOS1AP involves an unexpectedly complex interplay
between two distinct interaction sites. Each site is potentially druggable,
thereby providing increased opportunities for therapeutic intervention. This is
of potential interest considering that the NR-PSD95-nNOS complex and
potentially the recruitment of NOS1AP may be involved in some of the most
common causes of death and disability from stroke to neuropathic pain,
depression and anxiety disorders, while NOS1AP has been genetically linked to
schizophrenia, post-traumatic stress disorder, sudden cardiac death and long QT

All welcome to attend,

Jochen Prehn


Title: Sox2, more than a transcription factor Speaker: Dr. Pengyan Xia

Dr. Pengyan Xia

Sox2, more than a transcription factor

Date: Thursday 30thApril 2015

Dear Colleagues,

The Centre for Systems Medicine is pleased to announce another speaker of our seminar series, Dr Pengyan Xia.

Dr Xia’s research is focussed on
studying development and differentiation of the haematopoietic system, in
particular in self-renewal of haematopoietic stem cells (HSCs) and anti-microbe
activity of white blood cells that derived from HSCs. Specifically, his
research is focussed on signalling platforms that regulate the
self-renewal of HSCs (Xia et al, J Exp Med 2014) as well as extracellular
DNA triggered innate immunity in neutrophils (Xia et al, Nat Immunol 2015).

You are all very welcome to attend, please register


Markus Rehm

Centre for Systems Medicine, Department of Physiology and Medical Physics

Royal College of Surgeons in Ireland

Funded by the International Strategic Cooperation
Award (ISCA) Grant Number SFI/13/ISCA/2845 China

MEL-PLEX Worshop Wednesday 6th May 2015

Innovative Approaches in Translational Melanoma Research

MEL-PLEX is a Marie Skłodoswska-Curie
Innovative Training Network funded by Horizon 2020 aiming to train a new
generation of researchers that can navigate confidently between clinical,
academic and private sector environments. As part of its training programme,
MEL-PLEX will hold a training course which will consist of workshop to provide
an overview of the current status of malignant melanoma management and the
field of translational cancer systems biology and systems medicine, followed by
a Transferable Skills course to introduce the new PhD students to basic topics
in scientific research.

The main topics addressed

  • Melanoma
    pathology and treatment
  • Melanoma
    proliferation and migration
  • Kinase
    cascades in melanoma
  • Cell
    death modalities in melanoma
  • Biomarker
    identification and validation
  • Targeted
    drugs and drug development
  • Innovative
    experimental models
  • Applied
    Systems Biology
  • Systems
    Medicine strategies

The workshop entitled “Innovative
Approaches in Translational Melanoma Research” is an open event. Deadline for
registration is April 24th 2015.

For more information and free
registration please contact:

Venue: Cheyne Lecture Theatre, RCSI, 9am
Wednesday 6th May 2015