Ischaemic stroke and neurodegenerative disorders are leading causes of death and disability worldwide and constitute a significant burden to patients and their families. With the increase in life expectancy across the world, the incidence of these disorders is increasing rapidly. Despite improvements in prevention and emergency treatments for stroke, current treatment regimes are limited in their effectiveness due to a lack of understanding of the development of the neuronal injury within the brain. This results at least in part from limitations in our understanding of why neurons die or survive after stroke. Likewise, for most fatal and progressive neurodegenerative disorders there currently is no cure, and only very limited treatment options exist that address the symptoms but not the cause of the disease. We therefore aim to understand the underlying key pathophysiological processes, and from this to develop new therapeutic strategies.